Results 51 to 60 of about 681,124 (262)

Safety and efficacy of anti-PD-1 in patients with baseline cardiac, renal, or hepatic dysfunction

Journal for ImmunoTherapy of Cancer, 2016
Background Anti-PD-1 therapy is increasingly used in various advanced malignancies. Patients with baseline organ dysfunction are largely excluded from clinical trials. Therefore it is unclear whether anti-PD-1 therapy is safe or effective in this setting.
Igor Puzanov, Suthee Rapisuwon, Leora Horn, Bridgette A. Kanz, Megan H. Pollack, Romany Johnpulle, Alicia Morgans, Jeffrey A. Sosman, R. Martin Conry, Zeynep Eroglu, Douglas B. Johnson   +10 more
doaj   +1 more source

Perspective: A Framework to Screen Pediatric and Adolescent Hematopoietic Cellular Therapy Patients for Organ Dysfunction: Time for a Multi-Disciplinary and Longitudinal Approach

Frontiers in Oncology, 2021
Hematopoietic Cell Transplantation (HCT) is a potentially curative therapy for children and adolescent/young adults (AYA) with high-risk malignancies as well as some non-malignant genetic diseases.
Ali H. Ahmad, Kris M. Mahadeo
doaj   +1 more source

Not All Antibodies Are Created Equal: Factors That Influence Antibody Mediated Rejection. [PDF]

, 2017
Consistent with Dr. Paul Terasaki's "humoral theory of rejection" numerous studies have shown that HLA antibodies can cause acute and chronic antibody mediated rejection (AMR) and decreased graft survival. New evidence also supports a role for antibodies
Butler, Carrie L, Reed, Elaine F, Thomas, Kimberly A, Valenzuela, Nicole M   +3 more
core   +4 more sources

THE PATIENT-SPECIFIC INJURY SCORE: PRECISION MEDICINE IN TRAUMA PATIENTS PREDICTS ORGAN DYSFUNCTION AND OUTCOMES [PDF]

, 2016
poster abstractIntroduction: Current injury scoring systems in polytraumatized patients are limited at predicting patient outcomes. We present a novel method that quantifies mechanical tissue damage and cumulative hypoperfusion using a precision medicine
Bakdash, K., Brown, K., Cutshall, A., Gaski, G.E., McCarroll, T., McKinley, T.O., Metzger, C., Savage, S., Steenberg, S., Zarzaur, B.   +9 more
core  

The impact of duration of organ dysfunction on the outcome of patients with severe sepsis and septic shock

Clinics, 2008
OBJECTIVES: This study aimed to assess the impact of the duration of organ dysfunction on the outcome of patients with severe sepsis or septic shock. METHODS: Clinical data were collected from hospital charts of patients with severe sepsis and septic ...
Flávio G. R. Freitas, Reinaldo Salomão, Nathalia Tereran, Bruno Franco Mazza, Murillo Assunção, Mirian Jackiu, Haggeas Fernandes, Flávia Ribeiro Machado   +7 more
doaj   +1 more source

P50 implies adverse clinical outcomes in pediatric acute respiratory distress syndrome by reflecting extrapulmonary organ dysfunction

Scientific Reports, 2022
Hypoxemia and multiple organ dysfunction are significant contributors to mortality in patients with pediatric acute respiratory distress syndrome (PARDS).
Yura Kim, Jae Hwa Jung, Ga Eun Kim, Mireu Park, Myeongjee Lee, Soo Yeon Kim, Min Jung Kim, Yoon Hee Kim, Kyung Won Kim, Myung Hyun Sohn   +9 more
doaj   +1 more source

Different behaviour of BK-virus infection in liver transplant recipients [PDF]

, 2016
Polyomavirus BK (BKV) infects up to 90% of the general population. After primary infection, occurring early during childhood, a state of non-replicative infection is established in the reno-urinary tract, without complications for immunocompetent hosts ...
MITTERHOFER, Anna Paola, Muiesan, Paolo, TINTI, FRANCESCA, UMBRO, ILARIA   +3 more
core   +3 more sources

Characteristics and risk factors associated with critical illness in pediatric COVID-19

Annals of Intensive Care, 2020
Background While much has been reported regarding the clinical course of COVID-19 in children, little is known regarding factors associated with organ dysfunction in pediatric COVID-19. We describe critical illness in pediatric patients with active COVID-
Grace Fisler, Stephanie M. Izard, Sareen Shah, Deirdre Lewis, Mundeep K. Kainth, Stefan H. F. Hagmann, Joshua A. Belfer, Lance M. Feld, Fiore Mastroianni, Charlotte L. Kvasnovsky, Christine A. Capone, James Schneider, Todd Sweberg, Charles Schleien, Matthew D. Taylor, the Northwell COVID-19 Research Consortium   +15 more
doaj   +1 more source

Is intra-abdominal hypertension a missing factor that drives multiple organ dysfunction syndrome? [PDF]

, 2014
In a recent issue of Critical Care, Cheng and colleagues conducted a rabbit model study that demonstrated that intra-abdominal hypertension (IAH) may damage both gut anatomy and function. With only 6 hours of IAH at 25 mmHg, these authors observed an 80%
De Waele, Jan, Kirkpatrick, Andrew W, Laupland, Kevin, Roberts, Derek J   +3 more
core   +2 more sources

Multiple Organ Dysfunction (MODS) in Sepsis

Journal of Pediatric Critical Care, 2018
Sepsis is one of the life-threatening condition affecting many children. A continuum of severity from sepsis to septic shock and MODS exists. The emergence of MODS as a clinical entity is one of the hallmark challenges of the modern era of critical care ...
G V Basavaraja, S Uday Shankar
doaj   +1 more source