Results 61 to 70 of about 2,384,805 (255)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Organ Donation and Transplant Ireland – Annual Report 2016
, 2017 This report outlines the rates of organ donation and transplantation in Ireland in 2016. Thanks to the generosity of 77 families donating organs after death and 50 living donor kidney transplants, 280 people have received the gift of life through ...
Organ Donation and Transplant Ireland (ODTI)
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Identity and adjustment: experiences of the organ transplant recipient [PDF]
, 2015 Positive health-related behaviour is particularly important for liver transplant recipients’ (LTRs) recovery. However, non-adherence in adolescents post-transplant is thought to be greater than, or equal to, 50%.
Falk, R.
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AUXIN RESPONSE FACTOR 18-HISTONE DEACETYLASE 6 module regulates floral organ identity in rose (Rosa hybrida). [PDF]
Plant Physiol, 2021 Chen J +13 more
europepmc +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Windlines. Volume 1, number 3 (March 2008)
, 2008 Third issue of the American Organ Institute newsletter, contains pictures from the removal of the G. H.Hille Memorial Wurlitzer and the Moller Op. 5819, events at AOI during Spring 2008, "Technician's Corner" update about an average day at the organ shop,
American Organ Institute
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Windlines. Volume 5, number 2 (January 2012)
, 2012 Issue of the American Organ Institute newsletter; advertisement for concert by Ken Double and Skip Stine; "Principal Chorus" update announcing the creation of the American Theatre Organ Library at AOI based on the ATOS archives, congratulating students ...
American Organ Institute
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source