Results 171 to 180 of about 1,436,477 (401)

LncRNA‐MEG3 Regulates Muscle Mass and Metabolic Homeostasis by Facilitating SUZ12 Liquid–Liquid Phase Separation

open access: yesAdvanced Science, EarlyView.
This study has identified lncRNA‐MEG3 as a key regulator of muscle mass, promoting slow‐twitch muscle fibers and preventing muscle atrophy. By stabilizing the SUZ12/PRC2 complex through liquid–liquid phase separation (LLPS), lncRNA‐MEG3 influences mitochondrial function and lipid metabolism.
Yilong Yao   +15 more
wiley   +1 more source

Targeting Antigen‐Presenting Cells to Enhance the Tumor‐Spleen Immunity Cycle through Liposome‐Neoantigen Vaccine

open access: yesAdvanced Science, EarlyView.
LNPsD18, a cationic liposome that enhances antigen‐presenting cell uptake in the spleen and tumor without targeting ligands is developed. Co‐delivering neoantigens and a TLR9 agonist significantly improve DC activation, tumor immunity, and survival in liver and colorectal cancer models, demonstrating the importance of dual‐site APC targeting for cancer
Yu Xu   +12 more
wiley   +1 more source

A Rural Hospital\u27s Organ Donation Referral Pattern : A Pilot Study [PDF]

open access: yes, 2003
It is unclear if hospitals correctly refer all potential organ donors to Organ Procurement Organizations. Unidentified or mis-referred patients may be present in rural acute care Appalachian hospitals. A one-year nonexperimental retrospective descriptive
Carter, Chris F.
core   +1 more source

Synergistic Modulating of Mitochondrial Transfer and Immune Microenvironment to Attenuate Discogenic Pain

open access: yesAdvanced Science, EarlyView.
Gallic acid (GA) and copper ions self‐assemble to form nanoparticles, which are then modified with mitochondrial targeting peptides and gap junction modulator. These nanoparticles scavenge mitochondrial reactive oxygen species to induce M2 polarization and enhance intercellular mitochondrial transfer.
Xinzhou Wang   +13 more
wiley   +1 more source

The role of green innovation and hope in employee retention

open access: yesBusiness Strategy and the Environment, Volume 32, Issue 1, Page 220-239, January 2023., 2023
Abstract Green innovation is increasingly receiving attention in organisational behaviour and strategic management literature. However, understanding employee's preferences for organisations that have adopted innovative environmental practices have received little attention. This study tests a framework that examines the relationship between employees'
Syed Muhammad Fazal‐e‐Hasan   +6 more
wiley   +1 more source

The Encapsulation Strategies for Targeted Delivery of Probiotics in Preventing and Treating Colorectal Cancer: A Review

open access: yesAdvanced Science, EarlyView.
This work summarizes the efficacy and mechanisms of probiotics in CRC treatment, providing a comprehensive overview of various encapsulation methods such as microcapsules, hydrogels, single‐cell nanocoatings, and nanofibers for targeted probiotic delivery to inflammatory sites, with particular emphasis on the potential advantages of emerging single ...
Hao Zhong   +5 more
wiley   +1 more source

Optimal Procurement Design: A Reduced Form Approach [PDF]

open access: yesarXiv
Standard procurement models assume that the buyer knows the quality of the good at the time of procurement; however, in many settings, the quality is learned only long after the transaction. We study procurement problems in which the buyer's valuation of the supplied good depends directly on its quality, which is unverifiable and unobservable to the ...
arxiv  

Organ transplantation--then and now. [PDF]

open access: yes, 1987
The last 25 years have seen amazing progress in transplantation--from the development of techniques for immunosuppression to methods for organ removal and preservation.
Makowka, L, Starzl, TE
core  

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