Results 291 to 300 of about 1,382,675 (358)

Waxy‐ or Putty‐Like Materials as a Novel Drug Preparation for Synthetic Cannabinoid Receptor Agonists: Detection in Prisons and In Vitro Cannabinoid Receptor Activity

open access: yesDrug Testing and Analysis, EarlyView.
Waxy‐ or putty‐like materials has emerged as a novel drug preparation for synthetic cannabinoids and other drugs in UK prisons. An in vitro CB1 bioassay was used to evaluate the CB1 activating potential of MDMB‐INACA and extracts from eight seized samples. MDMB‐INACA had moderate efficacy but low potency at CB1.
Axelle Timmerman   +9 more
wiley   +1 more source

Identification and Investigation of the Intrinsic Receptor Activation Potential and Metabolization of the New Oxo‐Pyridyl Synthetic Cannabinoid Receptor Agonist CH‐FUBBMPDORA

open access: yesDrug Testing and Analysis, EarlyView.
Another Chinese generic ban‐evading SCRA, CH‐FUBBMPDORA, has emerged. This study reports its first identification in Europe, its analytical characterization (NMR, Raman, FTIR, GC–MS, and HRMS), its cannabinoid activation potential in a βarr2 recruitment assay, and its metabolization profile.
Marie H. Deventer   +13 more
wiley   +1 more source

Identification of Three Novel Tetrahydrocannabinol Analogs in the European Market

open access: yesDrug Testing and Analysis, EarlyView.
The major isolated ingredient of “CB9” was identified as [2‐(E)‐propen‐1‐yl]‐Δ8‐tetrahydrocannabinol‐acetate of “tresconol” as [2‐propen‐2‐yl]‐Δ9‐tetrahydrocannabinol and of “CBx” as [2‐propen‐2‐yl]‐Δ8‐tetrahydrocannabinol. These compounds have no available spectroscopic or chromatographic data and have never been identified in Cannabis plants, and ...
Evangelos Dadiotis   +4 more
wiley   +1 more source

Quantitative Investigation of Nitrosamine Drug Substance‐Related Impurities (NDSRIs) Under Artificial Gastric Conditions by Liquid Chromatography–Tandem Mass Spectrometry and Structure–Activity Relationship Analysis

open access: yesDrug Testing and Analysis, EarlyView.
The study provides information about the impact of physiological gastric conditions on the unbeneficial occurrence of nitrosamine drug substance–related impurities (NDSRIs). Both main factors for nitrosation in the form of acidic conditions and the presence of nitrite were adequately chosen for triggering the conversion of drug compounds into NDSRIs ...
Matthias Vogel   +5 more
wiley   +1 more source

Infant Death due to Cannabis Ingestion

open access: yesDrug Testing and Analysis, EarlyView.
ABSTRACT A child died in the emergency room of a local hospital a few hours after ingesting a substance the color of cork and the consistency of earth. At home, a modest amount of resinous substance was found. At the hospital, the child exhibited alterations in walking, balance, and consciousness.
Donata Favretto   +9 more
wiley   +1 more source

Gels for CO2 geo‐storage and conformance control: A systemic review of behavior and performance

open access: yesDeep Underground Science and Engineering, EarlyView.
This review provides a systemic evaluation of potential sealants used in CO2 subsurface storage practices. Critical analyses of how external factors like CO2, pH, brine salinity and hardness, rock mineralogy, pressure, temperature, and injectivity could affect the performance of different sealants are provided. Abstract Carbon capture and storage (CCS)
Funsho Afolabi   +6 more
wiley   +1 more source

Hydrovoltaic Energy Harvesting From Nut Shells

open access: yesENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Schematic diagram illustrating the process of an NS‐based WEG. The flow diagram illustrates the preparations, porous hierarchical structure, water‐surface interactions, water transportation through channels and generating streaming potential. The center left demonstrates voltage/current generation through evaporation in graphite‐NS‐graphite sandwich ...
Nazmul Hossain   +5 more
wiley   +1 more source

Autopsy findings in cases of fatal COVID‐19 vaccine‐induced myocarditis

open access: yesESC Heart Failure, EarlyView.
Abstract COVID‐19 vaccines have been linked to myocarditis, which, in some circumstances, can be fatal. This systematic review aims to investigate potential causal links between COVID‐19 vaccines and death from myocarditis using post‐mortem analysis.
Nicolas Hulscher   +3 more
wiley   +1 more source

Home - About - Disclaimer - Privacy