Results 11 to 20 of about 13,374,903 (323)
Organ-Size Regulation in Mammals. [PDF]
Cold Spring Harbor Perspectives in Biology, 2015 The control of organism and organ size is a central question in biology. Despite the attention it has received, our understanding of how adult organ size is determined and maintained is still incomplete. Early work has shown that both autonomous and regulated mechanisms drive vertebrate organ growth, and both intrinsic and extrinsic cues contribute to ...
Alfredo I. Penzo-Méndez, B. Stanger
semanticscholar +3 more sources
Vitamin D stimulates cardiomyocyte proliferation and controls organ size and regeneration in zebrafish [PDF]
Dev Cell, 2019 SUMMARY Attaining proper organ size during development and regeneration hinges on activity of mitogenic factors. Here, we performed a large-scale chemical screen in embryonic zebrafish to identify cardiomyocyte mitogens.
Yanchao Han +13 more
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Overexpression of MtDof32 in Medicago truncatula enhances leaf and flower organ size through modulation of cell expansion [PDF]
Frontiers in Plant ScienceAs leaf organ size is a key determinant of plant morphology and development, elucidating the cellular and molecular mechanisms governing organ size regulation has become a central research focus in legume biology. DNA binding with one finger 32 (MtDof32),
Tao Guo +7 more
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Proliferation-independent regulation of organ size by Fgf/Notch signaling
eLife, 2017 Organ morphogenesis depends on the precise orchestration of cell migration, cell shape changes and cell adhesion. We demonstrate that Notch signaling is an integral part of the Wnt and Fgf signaling feedback loop coordinating cell migration and the self ...
Agnė Kozlovskaja-Gumbrienė +8 more
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Editorial: Control of plant organ size and shape [PDF]
Frontiers in Plant Science, 2022 Ran Xu +5 more
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Gαq controls organ size and developmental timing in Drosophila [PDF]
Cell Communication and SignalingThe G protein alpha subunit, Gαq, transduces extracellular signals from G-protein-coupled receptors (GPCRs) into the cell, playing essential roles in developmental processes such as organ size control, wound healing, and disease.
Maria F. Unger +8 more
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Evolution and conserved functionality of organ size and shape regulator PEAPOD. [PDF]
PLoS ONE, 2022 Transcriptional regulator PEAPOD (PPD) and its binding partners comprise a complex that is conserved throughout many core eudicot plants with regard to protein domain sequence and the function of controlling organ size and shape.
Ruth Cookson +8 more
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Feedback regulation of steady-state epithelial turnover and organ size [PDF]
Nature, 2017 Epithelial organs undergo steady-state turnover throughout adult life, with old cells being continually replaced by the progeny of stem cell divisions.
Jackson Liang +3 more
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PLoS Genetics, 2018 Organ size control is of particular importance for developmental biology and agriculture, but the mechanisms underlying organ size regulation remain elusive in plants.
Na Li +11 more
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Localized JNK signaling regulates organ size during development
eLife, 2016 A fundamental question of biology is what determines organ size. Despite demonstrations that factors within organs determine their sizes, intrinsic size control mechanisms remain elusive.
Helen Rankin Willsey +5 more
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