Results 211 to 220 of about 465,843 (360)

Optimal production of transplant care services. [PDF]

Most organ transplants are from dead donors. National transplant organizations exhibit considerable differences in terms of their donor population rates. Spain’s organization is by far the most efficient in this respect.
Bruno Deffains, Jean Mercier Ythier
core  

Lactylation‐Driven NUPR1 Promotes Immunosuppression of Tumor‐Infiltrating Macrophages in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Cai et al. report that tumor‐derived lactate induces NUPR1 expression via H3K18 lactylation, which can promote the pro‐tumor M2 macrophage polarization through ERK and JNK signaling pathways. Treatment with NUPR1 selective inhibitor sensitizes synergizes with anti‐PD‐1 therapy in murine preclinical models.
Jialiang Cai, Peiling Zhang, Yufan Cai, Guiqi Zhu, Shiping Chen, Lina Song, Junxian Du, Biao Wang, Weixing Dai, Jian Zhou, Jia Fan, Yiyi Yu, Zhi Dai   +12 more
wiley   +1 more source

Donor cell chimerism permitted by immunosuppressive drugs: a new view of organ transplantation [PDF]

, 1993
Thomas E. Starlz, Anthony J. Demetris, Noriko Murase, Angus W. Thomson, Massimo Trucco, Camillo Ricordi   +5 more
openalex   +3 more sources

Circadian immune system in solid organ transplantation: a review article. [PDF]

Front Immunol
Yim WY, Li C, Tong F, Hou J, Chen Y, Liu Z, Wang Z, Geng B, Wang Y, Dong N.   +9 more
europepmc   +1 more source

A Compound Screen Based on Isogenic hESC‐Derived β Cell Reveals an Inhibitor Targeting ZnT8‐Mediated Zinc Transportation to Protect Pancreatic β Cell from Stress‐Induced Cell Death

Advanced Science, EarlyView.
Pancreatic β cell loss by cellular stress contributes to diabetes pathogenesis. The study demonstrates that WFS1–ZnT8–zinc axis regulates vicious cycle of zinc transportation and cellular stress in pancreatic β cell. Based on that, the study applies a strategy for compound screening targeting ZnT8 based on human models, and identifies anisomycin, as a ...
Rui Hu, Qing Ma, Yunhui Kong, Zhaoyue Wang, Minglu Xu, Xiangyi Chen, Yajuan Su, Tinghui Xiao, Qing He, Xuan Wang, Wenjun Xu, Yiling Yang, Xushu Wang, Xiaobo Li, Yanfang Liu, Shuangshuang Chen, Rui Zhao, Meng Guo, Gaowei Wang, Weida Li   +19 more
wiley   +1 more source

Machine learning in solid organ transplantation: Charting the evolving landscape. [PDF]

World J Transplant
Rawashdeh B, Al-Abdallat H, Arpali E, Thomas B, Dunn TB, Cooper M.   +5 more
europepmc   +1 more source

An Agrin–YAP/TAZ Rigidity Sensing Module Drives EGFR‐Addicted Lung Tumorigenesis

Advanced Science, EarlyView.
The study identifies agrin‐EGFR mechanotransduction as a critical driver of lung adenocarcinoma which enhances EGFR signaling through an integrin‐FAK‐actomyosin dependent positive feedback on YAP/TAZ ‐TEAD in response to matrix stiffness. Targeting this oncogenic loop through combinatorial treatments inhibits lung cancer due to agrin impairment.
Reza Bayat Mokhtari, Divyaleka Sampath, Paige Eversole, Melissa Ong Yu Lin, Dmitriy A. Bosykh, Gandhi T.K. Boopathy, Aravind Sivakumar, Cheng‐Chun Wang, Ramesh Kumar, Joe Yeong Poh Sheng, Ellen Karasik, Barbara A. Foster, Han Yu, Xiang Ling, Wenjie Wu, Fengzhi Li, Zoë Weaver Ohler, Christine F. Brainson, David W. Goodrich, Wanjin Hong, Sayan Chakraborty   +20 more
wiley   +1 more source

Extracellular Vesicles and Immune Activation in Solid Organ Transplantation: The Impact of Immunosuppression. [PDF]

BioDrugs
Xu W, Boer K, Hesselink DA, Baan CC.
europepmc   +1 more source

Label‐Free Dual‐Modal Photoacoustic/Ultrasound Localization Imaging for Studying Acute Kidney Injury

Advanced Science, EarlyView.
This work develops a 3D label‐free photoacoustic/super‐resolution ultrasound imaging system as a comprehensive non‐invasive tool for acute kidney injury (AKI) study. This technique visualizes the intricate structure of renal microvessels and provides critical physiological insights, including renal hemodynamics and oxygenation.
Shensheng Zhao, Xingxing Zhang, Keith Bailey, Sathvik Pai, Yang Zhao, Yun‐Sheng Chen   +5 more
wiley   +1 more source

Regulatory B cells, the key regulator to induce immune tolerance in organ transplantation. [PDF]

Front Immunol
Liao J, Yang Y, Li J, Liu Z, Song S, Zeng Y, Wang Y.   +6 more
europepmc   +1 more source