Results 91 to 100 of about 2,112,824 (298)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
STUDY ON THE LEVEL OF CONFIDENCE THAT ROMANIAN CONSUMERS HAVE REGARDING THE ORGANIC PRODUCTS [PDF]
Scientific Papers Series : Management, Economic Engineering in Agriculture and Rural Development, 2015 Organic agriculture is a domain that is growing rapidly both in Europe or worldwide and in Romania. However, there is a limited number of researches which, by the used methodology, are able to offer a definite and appropriate image of the Romanian market
Narcis Alexandru BOZGA
doaj
Semi‐Transparent Tandem Organic Solar Cells with 90% Internal Quantum Efficiency [PDF]
, 2012 Zheng Tang +10 more
openalex +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Contrasting responses of root morphology and root-exuded organic acids to low phosphorus availability in three important food crops with divergent root traits [PDF]
, 2015 Yanliang Wang +7 more
openalex +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Sustaining Soil Health in High Tunnels: A Paradigm Shift toward Soil-centered Management
HortTechnologyThis review was conducted to synthesize current knowledge, learn producer and Extension specialist perspectives, and identify gaps in understanding of the role of soil health in sustaining production in high tunnel (HT) systems.
Jacques Fils Pierre +15 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source