Results 121 to 130 of about 1,778,054 (221)

Near‐Infrared Fluorescent PROTAC Enables Theranostic Imaging and Selective Tau Degradation in Alzheimer's Disease

Advanced Science, EarlyView.
Here, we report a novel NIR fluorescent PROTAC platform that enables real‐time imaging and targeted degradation of Alzheimer's p‐Tau. Our lead compound effectively clears p‐Tau, reduces APP/Aβ, and alleviates cognitive deficits in AD mice. This work demonstrates a theranostic strategy for visualizing degradation and developing next‐generation AD ...
Ziwei Ren, Qian Yue, Ning Gao, Qiu‐Lian Hao, Yan Huo, Chuchu Li, Xinyue Leng, Lu‐Lu Sun, Maggie Pui Man Hoi, Hai‐Hao Han, Mingliang Ma, Xu‐Wen Li   +11 more
wiley   +1 more source

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

Advanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen, Ying Ma, Lixuan Huang, Xin Chen, Fanliang Kong, Zhenzhou Qian, Mingyue Guan, Xinlin Wang, Yanyan Yang, Shasha Zhang, Peng Li, Renjie Chai   +11 more
wiley   +1 more source

Conducting Polymer Microcups for Organic Bioelectronics and Drug Delivery Applications. [PDF]

Adv Mater, 2017
Antensteiner M, Khorrami M, Fallahianbijan F, Borhan A, Abidian MR.   +4 more
europepmc   +1 more source

Beyond Conventional: A Review of Phytochemical‐Hydrogel Systems Enhanced by AI and 3D Printing for Chronic Wound Management

Advanced Science, EarlyView.
This review systematically bridges chronic wound pathology with natural phytochemical hydrogel therapeutics. A pathology‐to‐phytochemical mechanistic mapping framework is established, linking specific wound hallmarks to targeted phytochemical interventions.
Yitao Zhou, Xing Liu, Cuiyi Wang, Xiaoxuan Zhao, Pengrun Zhang, Jingjing Gu, Qiuhua Sun, Malcolm Xing, Yeqin Yang   +8 more
wiley   +1 more source

Continuous Molecular Monitoring Using Electrochemical Aptamer‐Based Sensors: Remaining Challenges for Long‐Term In Vivo Deployment

Advanced Science, EarlyView.
Continuous molecular monitoring using electrochemical aptamer‐based sensors enables real‐time tracking of dynamic biomarkers with transformative potential for precision medicine. Achieving clinically relevant month‐long stability remains a central challenge due to multiple degradation pathways.
Shibo Liu, Xiangling Li, Wei Ouyang
wiley   +1 more source

Organic bioelectronics probing conformational changes in surface confined proteins. [PDF]

Sci Rep, 2016
Macchia E, Alberga D, Manoli K, Mangiatordi GF, Magliulo M, Palazzo G, Giordano F, Lattanzi G, Torsi L.   +8 more
europepmc   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Conjugated Polymer‐Microbe Interactions Trigger Regulatory Reprogramming for Enhanced Bioelectrocatalysis

Advanced Science, EarlyView.
Conjugated polymer‐supported bioelectrochemical systems are shown to enhance microbial electrosynthesis by triggering coordinated electrochemical, transcriptional, post‐transcriptional (sRNA), metabolic, and protein‐level responses. Integrated multi‐omics and electrochemical analyses reveal selective physiological remodeling associated with improved ...
David Ohayon, Yuanmei Liang, Zexuan Wang, Jee Loon Foo, Glenn Quek, Samantha R. McCuskey, Zhongxin Chen, Matthew Wook Chang, Guillermo C. Bazan   +8 more
wiley   +1 more source

Robust, Breathable and Stretchable Liquid Metal Composite Nanofibre for Physiological Electrical Signal Monitoring

Advanced Science, EarlyView.
A conductive TPU/liquid‐metal nanofibrous film is fabricated via ultrasonic dispersion, electrospinning, and mold imprinting. The film is breathable, stretchable, deformation‐stable, and provides electromagnetic shielding. n‐Butanol encapsulation mitigates liquid‐metal surface tension and improves biocompatibility. Stable ECG, EOG, EEG, and EMG signals
Cong Huang, Zhenyu Chen, Zedong Jiang, Yuhao Jiang, Haohong Jiang, Zhenli Zhou, Yunlu Pan, Shu‐Jen Wang   +7 more
wiley   +1 more source

Modifying Electrochemical Doping in Light‐Emitting Electrochemical Cells With Gold Nanoparticles

Advanced Science, EarlyView.
This study shows that gold nanoparticles placed at an electrode can control how electrochemical doping occurs in organic electronic devices. Particularly, in light‐emitting electrochemical cells, by shifting the light‐emitting region, device efficiency is improved without altering the emissive material. This approach provides a simple and effective way
Ajay K. Poonia, Anton Kirch, Joan Ràfols‐Ribé, Lucrezia Catanzaro, Anish Rao, Karol Kołątaj, Vittorio Scardaci, Giuseppe Compagnini, Guillermo P. Acuna, Ludvig Edman, Nicolò Maccaferri   +10 more
wiley   +1 more source