Results 81 to 90 of about 4,463,518 (291)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Titania-promoted carboxylic acid alkylations of alkenes and cascade addition-cyclizations [PDF]

, 2014
Photochemical reactions employing TiO and carboxylic acids under dry anaerobic conditions led to several types of C-C bond-forming processes with electron-deficient alkenes.
Andrew Mills (1307034), Christopher O’Rourke (1307025), Miller, Philip, Miller, P., Phillip Miller, Phillip Miller (1307028), O'Rourke, C.; id_orcid, Andrew Mills, John C. Walton (15114), O'Rourke, C., Manley, David W, Miller, Phillip, Roy T. McBurney (1295667), Manley, D.W., Roy T. Mcburney, John C. Walton, David W. Manley, Mills, Andrew, McBurney, R. T., McBurney, R.T., Walton, John C, McBurney, Roy T, David W. Manley (1307031), Walton, J.C., Manley, D. W., O'Rourke, Christopher, Mills, A., Walton, J. C., Mills, A.; id_orcid   +28 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

A convenient catalyst system for microwave accelerated cross-coupling of a range of aryl boronic acids with aryl chlorides [PDF]

, 2007
Article number 18A convenient microwave accelerated cross-coupling procedure between aryl chlorides with a range of boronic acids has been developed. An explanation for the low reactivity of highly fluorinated boronic acids in Suzuki coupling is provided.
Matthew L. Clarke, Marcia B. France, Edward J. Milton, Jose A. Fuentes, Clarke, Matthew L., France, Marcia B., Milton, Edward J., Fuentes, José A., Roff, Geoffrey J., Geoffrey J. Roff   +9 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Pyridine-Based Compounds: Optimized Synthesis, C–H Functionalization, and Anticonvulsant Screening for Neurological Therapeutics

Journal of Chemistry
A series of multifunctional pyridine-based derivatives was synthesized using optimized methodologies. These include N-, S-, and O-propargyl-substituted compounds, achieved through tailored reaction conditions to exploit the inherent nucleophilicity of ...
Shushanik Sh. Dashyan, Heghine H. Vardanyan, Eugene V. Babaev, Armen G. Ayvazyan, Ervand G. Paronikyan, Suren S. Mamyan, Nina G. Hobosyan, Valya V. Dabayeva, Ruzanna G. Paronikyan, Kristine V. Balyan   +9 more
doaj   +1 more source

Diastereoselective [Cu(MeCN)4BF4/BF3·Et2O]-Catalyzed Cyclopropenation of Alkynes: Asymmetric Synthesis of β-Amino-α-cyclopropenyl Phosphonates

SynOpen, 2017
The diastereospecific formation of β-amino-α-cyclopropenyl phosphonates has been achieved in moderate yields from the cyclopropenation of 1-alkynes with dialkyl α-diazophosphonates. The reaction was performed by using a combined catalyst consisting of Cu(
Haihong Ge, Shuang Liu, Yan Cai, Zenghui Gao, Siyi Du, Zhiwei Miao, Guixian Xie   +6 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source