Results 61 to 70 of about 278,037 (310)

Subcommissural organ, cerebrospinal fluid circulation, and hydrocephalus

Microscopy Research and Technique, 2001
Under normal physiological conditions the cerebrospinal fluid (CSF) is secreted continuously, although this secretion undergoes circadian variations. Mechanisms operating at the vascular side of the choroidal cells involve a sympathetic and a cholinergic innervation, with the former inhibiting and the latter stimulating CSF secretion.
Perez-Figares, JM, Jimenez, AJ, Rodriguez, EM   +2 more
openaire   +4 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Effects of Supplementation with Microminerals on Production Indicators and Blood, Feces, and Urine Traces of Grazing Alpaca (Lama lama)

Revista de Producción Animal, 2016
To analyze the effect of additional microminerals in the diet supplement on weight and diameter of alpaca fiber, the application of three doses of selenium and zinc (0.0; 1.0; and 1.5 cc) on the diet, on CRD factorial arrangement (3 x 2) + (3 x 2), was ...
Luis Alonso Chicaiza , Cristian Arcos Alvarez , Paola Lascano Armas , Julio Enrique Usca , Francisco Hernán Chancusig , Jorge Armas Cajas , Hernán Bastidas Pacheco , Maira Martínez Freire , Silvana Méndez García, Manuel Soria Parra , Gonzalo López Crespo , Raúl Guevara Viera   +11 more
doaj  

Assessing sustainable operational conditions of a bottoming organic Rankine cycle using zeotropic mixtures: An energy-emergy approach

Heliyon, 2023
In this work, an Organic Rankine Cycle system is used to produce electricity from the waste heat of an internal combustion engine (ICE). The toluene, and cyclohexane, are the selected pure fluids to be compared with the zeotropic mixtures.
Guillermo Valencia Ochoa, Andres Pedraza Caballero, Dora Villada Castilla   +2 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Direct H2S, HS− and pH Measurements of High‐Temperature Hydrothermal Vent Fluids With In Situ Raman Spectroscopy

Geophysical Research Letters, 2023
Hydrothermal H2S is an important energy source for hydrothermal ecosystems. However, it is difficult to obtain accurate hydrogen sulfide concentrations in high‐temperature hydrothermal fluids because they are highly susceptible to oxidation and ...
Lianfu Li, Zimeng Li, Richen Zhong, Zengfeng Du, Zhendong Luan, Shichuan Xi, Xin Zhang   +6 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Model for predicting oil testing fluid rheological parameters of Bohai Bay oilfield in wide temperature and pressure range

Journal of Engineering and Applied Science
The rheological parameters of oil testing fluids play a crucial role in safely conducting oil testing operations, protecting reservoirs, and maintaining wellbore integrity, which are greatly influenced by temperature and pressure.
Peng Ji, Yuhang Pang, Min Wang, Bangtang Yin, Zhiyuan Wang   +4 more
doaj   +1 more source