Results 71 to 80 of about 762,910 (314)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Advancing organic and low-input food. QLIF Integrated Research Project [PDF]

, 2009
The Integrated Project “Improving quality and safety and reduction of costs in the European organic and low input supply chains” (QLIF) was funded by the European Commission under the 6th Framework Programme for Research and Technological Development ...
Niggli, Urs
core  

Organic inputs

, 2018
Organic inputs are derived from the processing of plant and animal products that the farmer brings to his crop in order for it to express its production potential (they can be included as biological inputs).
Faure, Arthur, Roux, Emilie, Sarthou, Véronique   +2 more
openaire   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Determining the energy usage efficiency and economic analysis of broiler chickens raised under organic conditions

Indian Journal of Animal Sciences, 2016
This study was conducted to determine the energy usage efficiency of broiler chickens raised under organic conditions. To accomplish this goal, the energy input-output of every 1,000 broiler chickens raised in organic conditions was calculated ...
HAKAN INCI, BUNYAMÝN SOGUT, OSMAN GOKDOGAN, TUGAY AYASAN, TURGAY SENGUL   +4 more
doaj   +1 more source

Assessments of Humic Substances Application and Deficit Irrigation in Triploid Watermelon

HortScience, 2020
Soil organic matter degradation and water limitation caused by intense farming activities are some of the major threats affecting agricultural production.
Kuan Qin, Daniel I. Leskovar
doaj   +1 more source

Nitrogen management of organic winter wheat Decision-making through model-based explorations [PDF]

, 2005
In organic wheat, nitrogen is one of the key limiting factors responsible for irregular productivity and low quality (David et al, 2005b), 5 to 50 % less than conventionally managed crops (Nieberg and Schulze Pals, 1996).
David, C., Jeuffroy, M.H., Meynard, J.M.
core  

Lateral Marsh Edge Erosion as a Source of Sediments for Vertical Marsh Accretion [PDF]

, 2018
With sea level rise accelerating and sediment inputs to the coast declining worldwide, there is concern that tidal wetlands will drown. To better understand this concern, sources of sediment contributing to marsh elevation gain were computed for Plum ...
Barbier, Bauer, Blum, Blum, Cahoon, Cavatorta, Claessens, Cook, Costanza, Day, Day, Dhillon, Donnelly, Donnelly, Engelhart, Eyre, Fagherazzi, Fagherazzi, Foley, Forbrich, French, Ganju, Ganju, Geyer, Gittman, Gosselink, Hayden, Hein, Hobbs, Hopkinson, Hughes, Kirwan, Kirwan, Kirwan, Koch, Lane, Leonardi, Leonardi, Leonardi, Levin, Magirl, Marcus, Mariotti, Mariotti, Mariotti, Mattheus, McGeehin, McKee, Meade, Meade, Megonigal, Millette, Milliman, Mineau, Morris, Morris, Morris, Morris, Morris, Mudd, Pasternack, Pavich, Priestas, Rahmstorf, Raymond, Redfield, Redfield, Redfield, Reed, Rovere, Schmidt, Schwimmer, Sholkovitz, Stuiver, Swales, Syvitski, Townsend, Trimble, Vallino, Vallino, Walsh, Warrick, Warrick, Watson, Weston, Wilson, Wollheim, Wollheim, Worm, Yarbro, Zhao   +90 more
core   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Economic Efficiency of U.S. Organic Versus Conventional Dairy Farms: Evidence from 2005 and 2010 [PDF]

We estimate an input distance function for U.S. dairy farming to examine the competitiveness of organic and non-organic dairy production by system and size.
Gillespie, Jeffrey M., Hallahan, Charles B., Nehring, Richard F., Sauer, Johannes   +3 more
core   +1 more source