Results 121 to 130 of about 2,087,694 (316)

The Financial Aspect of Growing Organic Wine Grapes in the Vredendal District [PDF]

open access: yes
Confusion still exists regarding the meaning of the organic production system. It can be defined as a holistic production system which enhances the agricultural eco-system by prohibiting the use of synthetic production mediums.
Hough, Ella Christina, Nell, Wilhelm T.
core   +1 more source

GROWING MEDIA FOR ORGANIC TOMATO PLANTLET PRODUCTION [PDF]

open access: yes, 2001
The choice of growing media and the strategy of application of organic fertilizers is considered one of the largest challenges for production of organic tomato plantlets for transplanting.
Nielsen, Kai Lønne   +1 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Sand mining deteriorates soil fertility and farming livelihoods around Accra, Ghana

open access: yesScientific Reports
Urbanization in Sub-Saharan Africa requires vast quantities of sand to meet infrastructural demands. In Accra, Ghana, sand mining occurs predominantly on farmlands at the city’s periphery. We selected three study communities to assess the effects of sand
Katharina Salomea Hemmler   +3 more
doaj   +1 more source

A convenient synthesis of CHF2O-containing pyrrolidines and related compounds — Perspective building blocks for drug discovery

open access: yesSynOpen
Fluorine-containing organic molecules, including CHF2O-derivatives, are among the most sought-after in medicinal chemistry. In the current work, a mini-library of 21 compounds with a CHF2O-motif incorporated with azetidine, pyrrolidine (proline ...
Kostiantyn Levchenko   +3 more
doaj   +1 more source

Organic milk production based entirely on home-grown feed [PDF]

open access: yes, 2004
The aim of the Ph.D. project was to examine the consequences for the farm of an organic milk production based entirely on home-grown feed. The project included interviews that identified what in farmers’ opinion is crucial for obtaining organic milk ...
Mogensen, Lisbeth
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

AVAILABLE from ANR: Organic Strawberry Production Manual and Prune Production Manual

open access: yesCalifornia Agriculture, 2013
California Agriculture - All ...
California Agriculture
doaj  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

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