Results 81 to 90 of about 530,757 (309)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Synthesis of new tetra- and pentacyclic, methylenedioxy- and ethylenedioxy-substituted derivatives of the dibenzo[c,f][1,2]thiazepine ring system

Beilstein Journal of Organic Chemistry
New tetra- and pentacyclic derivatives of the dibenzo[c,f][1,2]thiazepine ring system have been synthesized. The target compounds contain methylenedioxy or ethylenedioxy substituents linked to the benzene ring.
Gábor Berecz, András Dancsó, Mária Tóthné Lauritz, Loránd Kiss, Gyula Simig, Balázs Volk   +5 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Studies on the syntheses of β-carboline alkaloids brevicarine and brevicolline

Beilstein Journal of Organic Chemistry
A new total synthesis of the β-carboline alkaloid brevicarine is disclosed. The synthesis was carried out starting from an aromatic triflate key intermediate, allowing the introduction of various substituents into position 4 of β-carboline by cross ...
Benedek Batizi, Patrik Pollák, András Dancsó, Péter Keglevich, Gyula Simig, Balázs Volk, Mátyás Milen   +6 more
doaj   +1 more source

Estimation of interaction energy of some functional groups of medical substances with protein molecules in water condition [PDF]

, 2006
The basic energetic effects when forming organic substance complexes with protein molecules which determine thermodynamics of this process are examines using nonempirical quantum-chemical DFT method.
Bondarev, А. А., Smirnov, I. V.
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Volatilization of Benzene in a River

Undergraduate Journal of Mathematical Modeling: One + Two, 2013
Benzene is a volatile organic compound: when it contaminates a river, some of the substance will evaporate as it flows through. We examine the volumetric flow rate to find how volatilization affects the concentration levels of benzene as the substance ...
Eric Dunlop
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

UVA I-protection effectiveness of bioactive compound and organic UV filters: an in vitro assessment

Química Nova, 2009
This research work aimed at determining the UVA effectiveness (UVA I/UV ratio), by diffuse transmittance analysis, of sunscreens developed with a bioactive substance, the rutin, associating or not with organic UVB-UVA filters incorporated at a phosphate ...
André Rolim Baby, Tatiana Santana Balogh, Carla Aparecida Pedriali, Telma Mary Kaneko, Maria Valéria Robles Velasco   +4 more
doaj   +1 more source

Bioelectrical Methane Production with an Ammonium Oxidative Reaction under the No Organic Substance Condition. [PDF]

Microbes Environ, 2021
Dinh HTT, Kambara H, Harada Y, Matsushita S, Aoi Y, Kindaichi T, Ozaki N, Ohashi A.   +7 more
europepmc   +1 more source