Results 201 to 210 of about 104,442 (306)

Cultural adaptation of the workplace age-friendliness measure to German with validation in Austrian organizations. [PDF]

Gerontologist
Lang G, Eppler-Hattab R.
europepmc   +1 more source

Organising the Central State Administration [PDF]

SIGMA Papers, 2007
openaire   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Enablers and Barriers to the Implementation of the Allied Health Rural Generalist Education and Training Scheme in Rural and Remote Private and Non-Government Contexts in Australia. [PDF]

Aust J Rural Health
Dymmott A, McDonough C, Cleland J, Brebner C, George S, Campbell N, Worley P, Maloney C, Tuxworth G, Milte R.   +9 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Neglected tropical diseases elimination activities in South Sudan's largest refugee camp: lessons from 2 years of work. [PDF]

Int Health
Idraku J, Ajack JC, Budhwar S, Thiik M, Lopes S, Leff S, Bol YY, Badia-Rius X.   +7 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Why followership matters in psychiatry: rebalancing our obsession with leadership. [PDF]

BJPsych Open
Laugharne RA, Alexander RT, Kaufman KR, Tracy DK, Aria F, Deshpande M, Frost M, Shankar R.   +7 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Spatiotemporal mapping of brain organisation following the administration of 2C-B and psilocybin. [PDF]

Mol Psychiatry
Mallaroni P, Singleton SP, Mason NL, Satterthwaite TD, Ramaekers JG.   +4 more
europepmc   +1 more source