Results 41 to 50 of about 26,880 (295)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Organisational Privacy Culture and Climate: A Scoping Review

IEEE Access, 2022
New regulations worldwide are increasingly pressing organisations to review how they collect and process personal data to ensure the protection of individual privacy rights. This organisational transformation involves implementing several privacy practices (e.g., privacy policies, governance frameworks, and privacy-by-design methods) across multiple ...
Leonardo Horn Iwaya, Gabriel Horn Iwaya, Simone Fischer-Hubner, Andrea Valeria Steil   +3 more
openaire   +3 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Anomalous Reduction of the Total Suspended Matter During the COVID-19 Lockdown in the Hooghly Estuarine System

Frontiers in Marine Science, 2021
The impact of the coronavirus disease 2019 (COVID-19) lockdown in the Hooghly estuarine region, India is assessed using the total suspended matter (TSM) concentration.
Chiranjivi Jayaram, Rajdeep Roy, Neethu Chacko, Debadatta Swain, Ramunaidu Punnana, S. Bandyopadhyay, S. B. Choudhury, Dibyendu Dutta   +7 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Influence of rainfall-runoff extremes on coastal total suspended solids (TSS)

Environmental Research Communications
The distribution of Total Suspended Solids (TSS) is a key indicator of water quality and overall coastal ecosystem health. Long-term, high-resolution satellite imaging enables the effective monitoring of coastal water quality for climate impact ...
S L Kesav Unnithan, Nagur Cherukuru, Tim Ingleton, Eric Lehmann   +3 more
doaj   +1 more source

Precise Orbit Determination for Climate Applications of GNSS Radio Occultation including Uncertainty Estimation

Remote Sensing, 2020
Global Navigation Satellite System (GNSS) Radio Occultation (RO) is a highly valuable remote sensing technique for probing the Earth’s atmosphere, due to its global coverage, high accuracy, long-term stability, and essentially all-weather capability.
Josef Innerkofler, Gottfried Kirchengast, Marc Schwärz, Christian Pock, Adrian Jäggi, Yago Andres, Christian Marquardt   +6 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Particle Fluxes at the Australian Southern Ocean Time Series (SOTS) Achieve Organic Carbon Sequestration at Rates Close to the Global Median, Are Dominated by Biogenic Carbonates, and Show No Temporal Trends Over 20-Years

Frontiers in Earth Science, 2020
Particle fluxes at the Southern Ocean time series (SOTS) site in the Subantarctic Zone (SAZ) south of Australia (∼47°S, ∼142°E, 4600 m water depth) were collected from 1997 – 2017 using moored sediment traps at nominal depths of 1000, 2000, and 3800 m ...
Cathryn A. Wynn-Edwards, Cathryn A. Wynn-Edwards, Cathryn A. Wynn-Edwards, Elizabeth H. Shadwick, Elizabeth H. Shadwick, Elizabeth H. Shadwick, Diana M. Davies, Diana M. Davies, Diana M. Davies, Stephen G. Bray, Peter Jansen, Peter Jansen, Peter Jansen, Rebecca Trinh, Thomas W. Trull, Thomas W. Trull, Thomas W. Trull   +16 more
doaj   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source