Results 111 to 120 of about 1,584,945 (320)

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

The Dropout Crisis: Promising Approaches in Prevention and Recovery [PDF]

, 2004
The number of high school age students who do not complete high school is receiving increased attention as a serious challenge facing the educational system. This is happening for several reasons.
Adria Steinberg, Cheryl Almeida
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Implications of the Context of Production of Texts and their Textual Organization for the (Re)Construction of Meanings

The ESPecialist: Research in Language for Specific Purposes, 2011
This article aims at stating the importance of analysing the context of production of texts as well as their organization through the use of modalization.
Janete Zygmantas
doaj  

The training of university students for the promotion of reading: contributions from an extensionist conception

Revista MENDIVE, 2022
The article addresses the promotion of reading in the university from a formative conception in the university extension. Its objective was aimed at establishing a pedagogical conception of training for the promotion of reading in the context of the ...
Yudit Rovira Alvarez, Ernesto López Calichs, Aylen Rojas Valdés, Alicia María Gilimas Siles   +3 more
doaj  

TEACHING AND LEARNING PROCESS TO IMPROVE READING SKILLS FOR THE FIFTH GRADE STUDENTS OF SD NEGERI 11 NGRINGO, JATEN, KARANGANYAR [PDF]

, 2009
This final project report is written based on the job training that which was carried out by the writer at SD Negeri 11 Ngringo, Jaten. The purposes of the project are to describe the process, method and the problems and the solution in teaching and ...
Nurhidayah, Anik
core  

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Ghassan Kanafani and the Leninist Warriors of Palestine

Arab Studies Quarterly
Inspired by the broad reading of the works of Ghassan Kanafani, necessitated through the collective process of translating his Selected Political Writings, this article charts the influence of Leninism among a key group of Palestinian revolutionaries. It
Louis Brehony
doaj   +1 more source

SMOG (Simple Measure of Goobledygook) Readibility Index in Selecting Reading Materials and Reading Literacy Skills of Primary School Student

International Journal of Elementary Education
Reading materials for elementary school students generally do not have readability in accordance with the measurement results so that the literacy level of students is low, as shown by the survey results from the United Nations Educational, Scientific ...
Nida Dalillah, Febry Ismayanti, Ersa Azzahra, Suherli Kusmana, Ira Rahayu   +4 more
semanticscholar   +1 more source