Results 71 to 80 of about 1,488,753 (342)

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

open access: yesMolecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin   +14 more
wiley   +1 more source

Escuchar, hablar, leer y escribir: una aproximación desde la opción crítica [PDF]

open access: yes, 1994
This article tries to compile some of the main contributions to the study of the contents, about texts production, frorn the point of view of the teaching-learning process like an interactive and reflective process.
Aguilar, Consol
core   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

open access: yesMolecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane   +16 more
wiley   +1 more source

Los conocimientos previos en el proceso de aprendizaje de contenidos históricos en el contexto escolar [PDF]

open access: yes, 2016
Es de interés psicológico y didáctico estudiar la actividad cognoscitiva de los niños involucrada en el proceso de adquisición de conocimientos específicos en el contexto escolar. A partir de los presupuestos epistemológicos del constructivismo genético,
Cohen, Liliana Alicia
core   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

Інтенсифікація процесу вивчення мови в умовах високого інформаційного та психофізіологічного навантаження [PDF]

open access: yes, 2015
У статті розглядаються прийоми інтенсифікації вивчення мови у вищому військовому навчальному закладі в умовах високого інформаційного та психофізіологічного навантаження.
Іванцова, О. (O. Ivantsova)
core  

Enhancing Comprehension and Production of Argumentation through Critical Thinking Awareness-Raising

open access: yesLinguae &: Rivista di Lingue e Culture Moderne, 2018
Language pedagogy aims to equip learners with tools to cope critically with the complexity of the language input and rationally evaluate the authenticity of the data.
Mahlagha Akbari   +2 more
doaj   +1 more source

Integrated methods of teaching listening and speaking

open access: yesРенессанс в парадигме новаций образования и технологий в XXI веке, 2022
Due to the lack of time English teachers have per week for their subject, the best way to practice listening and speaking is integrating them. According to Bueno, Madrid and McLaren: "Listening is important for speaking because it establishes the good basis for successful communicative exchanges (2006:344).
openaire   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

Friends of the Public Libraries, Indiana Origins and Outlook [PDF]

open access: yes, 2001
"Where there are friends, there is wealth," wrote Titus Maccius Plaurus more than 2,000 years ago (An Invitation). An advocacy group in Syracuse, N.Y., whose interest lay in the promotion of the welfare of its community's branch libraries and main ...
Brown, Amme   +4 more
core  

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