Results 81 to 90 of about 1,584,945 (320)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

The Leading Journal in the Field: Destabilizing Authority in the Social Sciences of Management [PDF]

, 2010
217 p. : il , 20 x 13 cm.Libro ElectrónicoI am often told, “Don’t waste your time reading books, you’d be better off reading the leading journals in your field.” Unfortunately, the authors of this book have closely read some of those articles: examining ...
Butler, Nick, Carter, Pippa, Jackson, Norman   +2 more
core  

Irony's architecture: Reflections on a photographic research project [PDF]

, 2007
This paper presents a research approach based on irony, rather than certainty. Using Richard Rorty's conception of irony, we contend that much traditional research in management presents a final language which is implicit in both the construction of a ...
Bathurst, Ralph, Sayers, Janet, Symonds, Henry   +2 more
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Improving advanced learners' communication skills through paragraph reading and writing [PDF]

, 2007
Japanese learners of English have suffered from an inability to become competent communicators despite their large vocabulary and good grammar. This is mainly because their messages are not presented logically.
Miyasone, Mika
core  

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

ENGLISH TEACHING & LEARNING ACTIVITIES AT SDN TEGALREJO SURAKARTA [PDF]

, 2007
This final project is written based on the job training that the writer has done as a temporary English teacher in SDN Tegalrejo Surakarta. This final project is a report of the writer’s English teaching and learning activities there.
Pratiwi, Dewi Retno
core  

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Sequence and domain organization of scruin, an actin-cross-linking protein in the acrosomal process of Limulus sperm

Journal of Cell Biology, 1995
The acrosomal process of Limulus sperm is an 80-microns long finger of membrane supported by a crystalline bundle of actin filaments. The filaments in this bundle are crosslinked by a 102-kD protein, scruin present in a 1:1 molar ratio with actin. Recent
Michael Way, Mitchell C. Sanders, Célia R.S. Garcia, Jun Sakai, Paul Matsudaira   +4 more
semanticscholar   +1 more source

The uniting of Europe and the foundation of EU studies: revisiting the neofunctionalism of Ernst B. Haas [PDF]

, 2005
This article suggests that the neofunctionalist theoretical legacy left by Ernst B. Haas is somewhat richer and more prescient than many contemporary discussants allow. The article develops an argument for routine and detailed re-reading of the corpus of
Balassa B., Ben Rosamond, Christiansen T., De Vree J. K., Deutsch K. W., Deutsch K. W., Fearon J., Haas E. B., Haas E. B., Haas E. B., Haas E. B., Haas E. B., Haas E. B., Haas E. B., Hoffmann S., Hooghe L., Lindberg L. N., Lindberg L. N., Lindberg L. N., Mitrany D., Mitrany D., Moravcsik A., Mutimer D., Nye J. S., Pentland C., Risse T., Rosamond B., Ruggie J. G., Schmitter P. C., Schmitter P. C.   +29 more
core   +1 more source