Results 111 to 120 of about 6,064,909 (344)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A critical review of the exit-voice-loyalty-neglect literature:limitations, key challenges and directions for future research [PDF]

, 2017
The study of human behaviour holds a prominent role in organizational behavior literature. For almost 45 years, the exit, voice, loyalty and neglect typology has attracted scholars’ interest and has been linked to employee responses towards ...
Aravopoulou, Eleni, Malone, Charles, Mitsakis, Fotios V.   +2 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The dark side of workplace personality: Examining the relationship between Horney's neurotic needs, self-esteem and the High Potential Trait Indicator (HPTI)

Acta Psychologica
This exploratory study examined demographic, self-esteem, and work-personality correlates of a measure of Horney's Neurotic Needs: Moving Away (Detachment), Moving Against (Aggression), and Moving Toward (Compliance) Others.
Adrian Furnham, Stephen Cuppello, Njabulo Mhlanga, David S. Semmelink   +3 more
doaj   +1 more source

Organizational culture, leadership style and effectiveness: A case study of middle eastern construction clients [PDF]

, 2013
During the last few decades, organizational effectiveness has received a great deal of attention in many industrial sectors. As a result, a variety of models have been formulated which measure organizational performance. In the construction industry, two
Adams, Jens, Ameri, Tayebeh, Brabec, Christoph J., Krebs, Frederik C., Langner, Stefan, Li, Ning, Lucera, Luca, Machui, Florian, Salvador, Michael, Spyropoulos, George D., Strohm, Sebastian, Voigt, Monika M., Zhang, Hong   +12 more
core   +1 more source

The Impact of Servant Leadership on Organization Culture, Organizational Commitment, Organizational Citizenship Behaviour (OCB) and Employee Performance in Women Cooperatives

, 2016
This paper aimed to analyze the impact of servant leadership on organizational culture, organizational commitment, OCB; and employee performance; organization culture on OCB and employee performance; organization commitment on OCB and employee ...
Wiwiek Harwiki
semanticscholar   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

An environment for object-oriented real-time system design [PDF]

, 1997
A concise object-oriented method for the development of real-time systems has been composed. Hardware components are modelled by (software) base objects; base objects are controlled by a hierarchy of coordinator objects, expressed in an organizational ...
Engmann, R.G.R., ten Thij, Vincent, van de Hoef, R., van de Hoef, Raoul, van de Weg, R.L.W.   +4 more
core   +3 more sources

Environmental considerations in the organizational context: A pathway to pro-environmental behaviour at work

, 2016
Encouraging pro-environmental behaviour at work can result in a significant reduction in environmental problems. Research revealed that general environmental considerations such as biospheric values and environmental self-identity are important ...
Angela Ruepert, K. Keizer, L. Steg, F. Maricchiolo, G. Carrus, A. Dumitru, R. G. Mira, A. Stancu, D. Moza   +8 more
semanticscholar   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source