Results 61 to 70 of about 67,464 (310)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

What are the determinants leading to innovation in manufacturing firms [PDF]

, 2013
In this paper, a comprehensive model of innovation determinants is analyzed based on empirical data gathered from 184 manufacturing firms located in the Northern Marmara region in Turkey.
Alpkan, Lutfihak, Alpkan, Lütfihak, Gunday, Gurhan, Günday, Gürhan, Kilic, Kemal, Kılıç, Kemal, Ulusoy, Gunduz, Ulusoy, Gündüz   +7 more
core  

Business strategy and innovativeness: results from an empirical study [PDF]

, 2012
This study reports on the testing of the hypothesis that there is a positive relationship between business strategy and innovativeness. Business strategy is defined here to include market focus strategy, technology development strategy, and operations ...
Alpkan, Lutfihak, Alpkan, Lütfihak, Gunday, Gurhan, Günday, Gürhan, Kilic, Kemal, Kılıç, Kemal, Ulusoy, Gunduz, Ulusoy, Gündüz   +7 more
core   +5 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Organizational Factors of Innovativeness in Serbian Enterprises

Naše Gospodarstvo, 2021
This paper analyses correlations between several organizational characteristics and product/process innovations in enterprises in Serbia. We used the World Bank Enterprise Survey data on 339 small, medium, and large companies from various industries ...
Pitić Goran, Vučković Aleksandar
doaj   +1 more source

Do organizational incentives spur innovation? [PDF]

BAR - Brazilian Administration Review, 2012
To date, we have only partially begun to develop an understanding of the channels through which innovation is facilitated within organizations. Although talented individuals are pivotal to supporting knowledge accumulation and renewal, they may be more willing to contribute new ideas if they expect to reap some of the gains that these ideas generate ...
Barros, Henrique M., Lazzarini, Sergio G.   +1 more
openaire   +4 more sources

Social network productivity in the use of SNS [PDF]

, 2010
Purpose – This paper aims to focus on the effect of intranet-based social networking services (SNS) on the activity of the firm, in particular on the change in the number of business connections and on the time and cost-savings brought about by such SNS ...
Magnier-Watanabe Rémy, Watanabe Tomoaki, Yoshida Michiko, マニエ　ワタナベ レミー   +3 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

An integrated innovation model: how innovations are born and what are their impacts on firm performance? [PDF]

, 2008
The main objective of this paper is to present a comprehensive and integrated model of innovation at the firm level and to discuss the effects of firm characteristics on the innovativeness capabilities of companies.
Alpkan, Lutfihak, Alpkan, Lütfihak, Gunday, Gurhan, Günday, Gürhan, Kilic, Kemal, Kılıç, Kemal, Ulusoy, Gunduz, Ulusoy, Gündüz   +7 more
core  

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source