Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal +3 more
wiley +1 more source
Public-Access Defibrillation in Megacities: Structural Barriers and Systemic Opportunities in Shanghai, China. [PDF]
Gao Y, Zhou X, Luo L.
europepmc +1 more source
CHANGING OF THE ORGANIZATIONAL CULTURE ‒ OPPORTUNITIES AND LIMITATIONS [PDF]
openaire +1 more source
Blending the ‘craft’ and ‘science’ of policing: challenges and opportunities for police as professional learning organizations [PDF]
Larissa Engelmann, Andrew Tatnell
openalex +1 more source
ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao +16 more
wiley +1 more source
Using normalization process theory to evaluate the implementation of a hybrid psychosocial prevention intervention in mental health care - a qualitative interview study. [PDF]
Gehrmann J +4 more
europepmc +1 more source
Climate Change Threatens Micronutrient Density of European Winter Wheat
Micronutrients are vital for human health. Wheat is a major staple crop and a significant source of minerals and B‐vitamins. The impact of climate change on their content remains largely unknown. We evaluated micronutrient levels in European winter wheat grown under historical and projected climate conditions. Our findings indicate that future climates
Da Cao +17 more
wiley +1 more source
AI-induced job crafting: a systematic review of cognitive appraisal pathways. [PDF]
Qiao Z.
europepmc +1 more source

