Results 81 to 90 of about 127,426 (254)
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Selecting the most suitable organizational structure for hospitals: an integrated fuzzy FUCOM-MARCOS method. [PDF]
Cost Eff Resour Alloc, 2022 Khosravi M, Haqbin A, Zare Z, Shojaei P.
europepmc +1 more source
Astrocyte heterogeneity in brain metastases
Molecular Oncology, EarlyView.Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver +2 more
wiley +1 more source
Challenges of the organizational structure of county health network in Iran: findings from a qualitative study. [PDF]
BMC Health Serv Res, 2022 Ghorrabi AT +3 more
europepmc +1 more source
From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care
Molecular Oncology, EarlyView.Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard +8 more
wiley +1 more source
Вестник Российского экономического университета имени Г. В. ПлехановаThe article studies methodological approach, advanced by the author, to using key predictors of organizational transformation necessary to forecast limits of feasible organization growth within the frames of the present production structure.
A. L. Bobkov
doaj +1 more source
Networked Organizational Structure of Enterprise Information Security Management Based on Digital Transformation and Genetic Algorithm. [PDF]
Front Public Health, 2022 Di Z, Liu Y, Li S.
europepmc +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Organizational Structure Change and Hybridity: Enhancing Uncertainty as a Response to Competing and Changing Institutional Logics. [PDF]
Front Psychol, 2022 Liu L, Zhang C.
europepmc +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source