FEBS Open Bio, EarlyView.The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez +4 more
wiley +1 more source
Examining types of Organizational Structure in Private Chartered Universities in Western Uganda and their Impact on Academic Staff Performance. [PDF]
F1000ResSilaji T, Bagiwa ZL, Muhammad T.
europepmc +1 more source
The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity
FEBS Open Bio, EarlyView.Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav +4 more
wiley +1 more source
A hierarchy index for networks in the brain reveals a complex entangled organizational structure. [PDF]
Proc Natl Acad Sci U S APathak A, Menon SN, Sinha S.
europepmc +1 more source
Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells
FEBS Open Bio, EarlyView.Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley +1 more source
Organizational Structure, Performance Monitoring, and Academic Staff Performance in Selected Private Chartered Universities: A Qualitative Study. [PDF]
Open Res AfrSilaji T, Bagiwa ZL, Muhammad T.
europepmc +1 more source
The Children's Oncology Group: Organizational Structure, Membership, and Institutional Characteristics. [PDF]
J Pediatr Oncol Nurs, 2019 Withycombe JS +5 more
europepmc +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Economic HorizonsIn the contemporary business environment characterized by risk and uncertainty, manufacturing companies need to focus on improving quality in every single aspect of their business model, with a focus on reaching the level of business excellence.
Jelena Erić Nielsen +2 more
doaj
Organizational structure, agility, and public value-driven innovation performance in the UAE public services. [PDF]
HeliyonAlmazrouei F +3 more
europepmc +1 more source