Results 71 to 80 of about 7,899,703 (296)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Towards a Model of Designing an Organizational Structure in a Knowledge Based Society [PDF]
The role of the manager in the knowledge society is to lead, in a productive and cost effective manner, a system that is at the crossroads of three worlds: the environment, the human and the organization. To ensure the continuity of the organization, the
Mihai Vărzaru, Eric Jolivet
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Modeling of common organizational structure for Reconfigurable Assembly System
, 2006 In order to response to the changing market and overcome the disadvantage of the traditional assembly line, based on decomposition of a product family into several so-called Functional Objects, a common organizational structure for Reconfigurable ...
Tan DL(谈大龙) +2 more
core
Rāhburdhā-yi Mudīriyyat dar Niẓām-i Salāmat, 2019 Background: In modern organizations, establishment and utilization of the entrepreneurial thinking are inevitable. Entrepreneurial thinking is considered as the insight and ability of the founders as well as the cause of the organizations' birth and ...
Ozhan Karimi +2 more
doaj
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
University Library at a New Stage of Social Communications Development, 2019 Objective. To study of the organizational information and analytical structures of libraries of top-rated universities in Ukraine, in particular, of 4 domestic universities that entered the World University Rankings 2019. Methods.
O. M. Kobelev
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
, 2018 Similar to other financial organizations, life insurance institutions are dealing with changes caused by the aging of the American population and technological advances. In addition, they are dealing with changes in the cultural and economic environment.
Krishnan, Rajesh R.
core