A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling +16 more
wiley +1 more source
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao +6 more
wiley +1 more source
Change in Organizational Structure Influences Perceived Leadership in a Dutch Radiotherapy Center. [PDF]
Swart RR +3 more
europepmc +1 more source
Lights up on organelles: Optogenetic tools to control subcellular structure and organization
Therese Kichuk +2 more
openalex +2 more sources
Crystal structure of a SeqA–N filament: implications for DNA replication and chromosome organization [PDF]
Alba Guarné +5 more
openalex +1 more source
Dementia Incidence in Individuals With Parkinson's Disease in the Framingham Heart Study
ABSTRACT Limited information exists on incident dementia in individuals with Parkinson's disease (PD) in US community‐based samples. We examined cognitive statuses and PD diagnoses of 183 individuals in the Framingham Heart Study (FHS) to establish incident dementia, mortality rates, associations with sex, age at PD onset, and education level.
Joshi Dookhy +11 more
wiley +1 more source
Changing the Organizational Structure and Enhancing Nurse-Staffing Levels Based on Patient Acuity in a Tertiary Referral Hospital. [PDF]
Martínez-Muñoz M +7 more
europepmc +1 more source
Value-based management in learning organizations through 'hard' and 'soft' managerial approaches: The case of Hewlett-Packard [PDF]
'Learning organizations' enable companies to remove hierarchical levels and to introduce a flatter organizational structure, which can lead to reduced costs and increased productivity.
Søren Nymark
core
THE RESEARCH ON AN INTER-ORGANIZATIONAL NETWORK STRUCTURE USING GRAPH THEORY TOOLS
Marta Danylovych-Kropyvnytska
openalex +2 more sources
Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach +23 more
wiley +1 more source

