Results 131 to 140 of about 7,899,703 (296)

Library as a social cluster information support

Библиосфера, 2015
The article analyzes modern library capability as a social cluster information support. A social cluster information support is offered to be considered not only as technological processes, but also as a process of intellectual resources exchange, that ...
O. Yu. Murashko
doaj  

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Method for automatic reorganization of the structure of multi-agent systems, based on the application of the simulated hardening algorithm

Известия высших учебных заведений. Поволжский регион:Технические науки
Background. The organizational structure of a multi-agent system includes many roles of agents, their horizontal and vertical connections, components that control their behavior, as well as rules for their functioning.
Yu.V. Dubenko, E.E. Dyshkant, A.A. Obozovskiy   +2 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Standard Operating Procedures and Organizational Learning [PDF]

We report results of a study on processes of Organizational Learning (OL). Changes and suspensions of organizational rules are taken as indicators for OL. The empiric analysis is performed with personnel rules of a German bank. The aim of our study is to
Beck, Nikolaus, Kieser, Alfred
core  

INDUSTRIAL ENTERPRISE MANAGEMENT SYSTEM QUALITY ASSESMENT

Модернизация, инновация, развитие, 2016
Management systems of small-scale enterprises in Moscow region are of centralized linear type. Misunderstanding of the need for qualitymanagement operational processes is observed in such business structures.
S. V. Pankov
doaj  

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Networks for change: How networks influence organizational change [PDF]

This paper contributes to the literature on organizational change by examining organizations as social entities embedded in inter-organizational networks.
Manuel Portugal Ferreira
core  

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

STRUCTURAL CHANGES IN THE PROCESS OF ORGANIZATIONAL TRANSFORMATIONS AT AN ENTERPRISE [PDF]

This article explores the critical role of structural changes in the process of organizational transformations within enterprises, focusing on how these changes impact organizational effectiveness and long-term development. In
MAZORENKO O., IVANCHENKOV V.
core