Results 81 to 90 of about 135,635 (216)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

Organize Yapılar Üzerindeki Hâkimiyette Dolaylı Faillik Kurumunun Haksızlık Teorisi Yardımıyla Gerekçelendirilmesi

open access: yesTürk-Alman Üniversitesi Hukuk Fakültesi Dergisi
Organize güç ilişkisine dayalı bir yapı içerisinde arkaplandaki kişinin tam sorumlu olan doğrudan failin işlediği suçtan dolayı dolaylı fail olarak cezalandırılması gerektiği görüşünün literatürde en yaygın gerekçesini oluşturan organizasyona egemenlik ...
Abdullah Yıldız
doaj   +1 more source

A survey of organizational structure and operational practices of elite youth football academies and national federations from around the world: A performance and medical perspective. [PDF]

open access: yesFront Sports Act Living, 2022
Gregson W   +10 more
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Library as a social cluster information support

open access: yesБиблиосфера, 2015
The article analyzes modern library capability as a social cluster information support. A social cluster information support is offered to be considered not only as technological processes, but also as a process of intellectual resources exchange, that ...
O. Yu. Murashko
doaj  

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