Results 121 to 130 of about 2,770,354 (303)
Behavioral SciencesReducing restrictive practices toward individuals with intellectual and developmental disabilities is a globally recognized imperative and human rights priority.
Victoria Sánchez-Gómez +3 more
doaj +1 more source
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
Digital transformation has become a strategic priority for healthcare organizations seeking to improve service delivery and achieve long-term organizational sustainability.
Damiete, Lawrence, Festus, Adigwe
core +1 more source
Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription
FEBS Open Bio, EarlyView.In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang +10 more
wiley +1 more source
SAGE OpenSmall and medium-sized enterprises (SMEs) operating in Thailand’s food manufacturing sector face increasing pressure to embrace digital transformation.
Darun Jewapatarakul +1 more
doaj +1 more source
FEBS Open Bio, EarlyView.KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph +7 more
wiley +1 more source
Organizational Transformation Based on Viral Change Management
Экономика и управление, 2019 This article presents the results of interdisciplinary studies as a model of viral organizational change management. Aim. The study aims to generate ideas and develop a new model of organizational change management characterized by a shorter change ...
Angelina A. Dolgaya
doaj
FEBS Open Bio, EarlyView.Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty +13 more
wiley +1 more source
Mastering the digital transformation through organizational capabilities : A conceptual framework
, 2023 As digital transformation is changing entire industries, organizations are struggling to keep up with these changes. Scholars are viewing organizational capabilities as a central mean for organizations to master digital transformation.
Konopik, Jens +4 more
core
In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols
FEBS Open Bio, EarlyView.Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton +6 more
wiley +1 more source