Results 41 to 50 of about 1,063,958 (260)

Business Research, Development, and Innovations in Economic Recession

open access: yesTeorie vědy, 2010
The article is devoted to the enterprise and state reactions against the impact of economic crisis on business R&D and innovation. It analyses strategic approaches and solution of enterprises during the crisis period with respect to ensuring ...
Karel Mráček
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Health system governance assessment in protracted crisis settings: Northwest Syria

open access: yesHealth Research Policy and Systems, 2023
Background Since the withdrawal of government forces from Northwest Syria due to the conflict, several national initiatives have aimed to create alternative governance approaches to replace the central governmental system.
Maher Alaref   +4 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Partisan differences in perceived levels of democracy across presidential administrations

open access: yesHumanities & Social Sciences Communications
Democracy in the United States is in decline. The current work examines to what degree U.S. Americans perceive this decline in the U.S., and how partisanship may shape those perceptions over time.
Gloria Danqiao Cheng   +2 more
doaj   +1 more source

Understanding the Role of Demographic and Psychological Factors in Users’ Susceptibility to Phishing Emails: A Review

open access: yesApplied Sciences
Phishing emails are malicious email messages that aim to deceive users into revealing sensitive information by imitating legitimate emails. These emails are usually among the first steps in most cyberattacks, often appearing as an urgent message ...
Alexandros Kavvadias   +1 more
doaj   +1 more source

Comparative Analysis of the Practice of Internet Use in the Marketing Activities of Higher Education Institutions in Poland and Ukraine

open access: yesComparative Economic Research, 2020
In the information age, the role of higher education as a factor of social progress is increasing. The competition among higher education institutions is also growing.
Artur Kisiołek   +2 more
doaj   +1 more source

The relationship between esophageal acidity and symptom frequency in symptomatic nonerosive gastroesophageal reflux disease

open access: yesPhysiological Reports, 2022
The present paper examines the extent to which novel measures of esophageal acid exposure can elucidate possible relationships between symptom perception and esophageal acidity in subjects with nonerosive gastroesophageal reflux disease.
Jerry D. Gardner
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

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