Results 171 to 180 of about 415,503 (309)
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Self-Organizing Neural Grove for Malware Detection in IoT Edge Devices. [PDF]
Sensors (Basel)Inoue H, Komura T, Hashimoto I.
europepmc +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Organizing on the edge: Heading to Mount Everest [PDF]
The paper analyzes complexity in organizations facing threatening environments. Such contexts are characterized by very high levels of risk and uncertainty that challenge organizational survival: fire-fighting, aerospace projects, high-tech research ...
Alvarez, Jose L., Montes, Juan S.
core
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Mapping the State of Financial Stability [PDF]
The paper uses the Self-Organizing Map for mapping the state of financial stability and visualizing the sources of systemic risks on a two-dimensional plane as well as for predicting systemic financial crises. The Self-Organizing Financial Stability Map (
Peltonen, Tuomas A., Sarlin, Peter
core
Ecological Integrity of Hybrid Ecosystems in the Anthropocene: The Impact of Self-Organization on Function and Sustainability. [PDF]
Ecol EvolGroner E, Peeters A, Shachak M.
europepmc +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source