Results 71 to 80 of about 519,048 (295)
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Early-Phase Market Organizing in Subsistence Settings
, 2018 This thesis studies early-phase market organizing. Contrary to dominant views of markets as neutral backgrounds to economic activity, in this work markets are understood as socio-material systems that are shaped by the actors involved in the organizing ...
Lindeman, Sara
core
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Self-Organizing Maps and the US Urban Spatial Structure [PDF]
This article considers urban spatial structure in US cities using a multi- dimensional approach. We select six key variables (commuting costs, den- sity, employment dispersion/concentration, land-use mix, polycentricity and size) from the urban ...
Daniel Arribas-Bel, Charles R. Schmidt
core
THE REGIONAL ECONOMIC PROGRESS AND THE NATURAL CHARACTERISTICS OF THE TERRITORIES
Journal of Bio-Based Marketing, 2023 This article is dedicated to the importance of the natural complex for the achievement of regional economic growth in individual territories. The presentation presents the topicality of the problem based on regional development and natural-geographical ...
Mihaela Georgieva1
doaj
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Cadernos de Letras da UFF, 2012 Organizers and program committee for the Intelligent Narrative Technologies 2012 AIIDE ...
openaire +10 more sources