Results 281 to 290 of about 40,189 (319)
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The Pathogenesis of Organophosphate Polyneuropathy
Critical Reviews in Toxicology, 1992This review discusses the facts regarding organophosphate-induced delayed polyneuropathy (OPIDP) as they are related to its pathogenesis rather than being a comprehensive review of all available data. Neuropathy target esterase (NTE) is considered to be the molecular target for OPIDP which is affected by several esterase inhibitors. Such inhibitors are
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The Alkylating Properties of Organophosphates
Xenobiotica, 19721. A brief introduction to the concept of alkylation is given, which discusses reaction mechanisms and reactivity, and includes an assessment of the susceptibility to alkylation of biologically-important molecules.2. A semi-quantitative colour test for alkylating agents, with 4-(p-nitrobenzyl) pyridine (NBP), has been modified to give a quantitative ...
J. Robinson, C. T. Bedford
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Therapy In Organophosphate Poisoning
Acta Clinica Belgica, 1976SummaryThe therapy of an intoxication by cholinesterase-inhibitors consists of the administration of atropine for symptomatic treatment, of the administration of oximes as a causal therapy and of general supportive measures. The dose of atropine is chosen according to the intensity of the poisoning; the therapeutic use of oximes is briefly discussed.
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Percutaneous Organophosphate Poisoning
Southern Medical Journal, 1987After cutaneous application of the organophosphate insecticide Diazinon for pubic lice, our patient had symptoms of cholinergic excess, lost consciousness, and had a seizure. Because of the high index of clinical suspicion for potentially lethal organophosphate poisoning, the patient received empiric therapy with pralidoxime and atropine and completely
Sloas Dd, Halle A
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Cardiodepression in Organophosphate Poisonings
1985During clinical epidemiological investigation of acute human organophosphate intoxication a cardiodepressive form of poisoning was recognised. It had a bad prognosis with a high incidence of lethality. The cardiodepressive form involved mechano- and electrodepression which were manifested in cardiogenic shock and sudden atrioventricular block or both ...
Marosi Gy. +2 more
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2001
Organophosphates - history, chemistry, pharmacology, T.C. Marrs socio-economics, health issues and pesticides, L. Karalliedde and T. Mereidith factors influencing organophosphate toxicity in humans, P. Edwards organophosphorus chemical warfare agents, T.C. Marrs and R.L. Maynard the acute cholinergic syndrome, L. Karalliedde and J.
J.A. Henry +3 more
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Organophosphates - history, chemistry, pharmacology, T.C. Marrs socio-economics, health issues and pesticides, L. Karalliedde and T. Mereidith factors influencing organophosphate toxicity in humans, P. Edwards organophosphorus chemical warfare agents, T.C. Marrs and R.L. Maynard the acute cholinergic syndrome, L. Karalliedde and J.
J.A. Henry +3 more
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Toxicology of Organophosphates and Carbamates
1987Toxicity of a chemical is dependant on several different but interconnected phases: a) factors which influence the delivery of the ultimate toxic agent to its site of action (absorption, distribution, storage, activation, detoxification); b) the reaction with the primary target (reversible or irreversible); c) the biochemical and physiological ...
MORETTO A, JOHNSON MK
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