Results 101 to 110 of about 2,535,633 (302)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Características de carcaça e rendimento de buchada de caprinos alimentados com farelo grosso de trigo em substituição ao milho Carcass characteristics and buchada dressing of goat fed rough wheat bran replacing corn

Revista Brasileira de Zootecnia, 2008
Objetivou-se determinar as características de carcaça e rendimento de buchada de caprinos alimentados com dietas com 0,0; 8,9; 19,8 ou 31,7% de farelo grosso de trigo (FGT) em substituição ao milho.
Argélia Maria Araújo Dias, Ângela Maria Vieira Batista, Francisco Fernando Ramos de Carvalho, Adriana Guim, Gilvan Silva, Aline Candido da Silva   +5 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Níveis de proteína bruta e suplementação de aminoácidos em rações para leitoas mantidas em ambiente de conforto térmico dos 30 aos 60 kg Crude protein levels of ration with amino acid supplementation to gilts maintained in a thermal comfort environment from 30 to 60 kg

Revista Brasileira de Zootecnia, 2005
Foi conduzido um experimento para determinar o nível de proteína bruta (PB) das rações com suplementação de aminoácidos para leitoas mestiças (Landrace x Large White) mantidas em ambiente de conforto térmico.
Uislei Antonio Dias Orlando, Rita Flávia Miranda de Oliveira, Juarez Lopes Donzele, Aloízio Soares Ferreira, Francisco Carlos de Oliveira Silva, Rafaela Antonia Ramos Generoso, Roberta Gomes Marçal Vieira Vaz, Jefferson Costa de Siqueira   +7 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Improved ultrasonic biomedical measuring apparatus [PDF]

, 1972
Device for making measurements of organs in living specimens and recording movements of organs is described. System uses series of ultrasonic pulses beamed into body of animal and reflected echo pulses are picked up by transducers and recorded.
Lee, R. D.
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Organs and universities: a universal association? [PDF]

, 2013
Short essay on the association between organs and ...
Butt, J.
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source