Results 61 to 70 of about 1,284,838 (261)

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Influência dos níveis de concentrado sobre os cortes comerciais, os constituintes não-carcaça e os componentes da perna de cordeiros confinados Effect of concentrate levels on retail cuts, non-carcass and leg components of crossbred feedlot lambs

Revista Brasileira de Zootecnia, 2007
Um experimento foi realizado com o objetivo de determinar a influência dos níveis de concentrado sobre o peso e o rendimento dos cortes e dos constituintes não-carcaça e a composição tecidual da perna de cordeiros mestiços de Dorper terminados em ...
Rossana Herculano Clementino, Wandrick Hauss de Sousa, Ariosvaldo Nunes de Medeiros, Maria das Graças Gomes Cunha, Severino Gonzaga Neto, Francisco Fernando Ramos de Carvalho, Maria Andréa Borges Cavalcante   +6 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Organizers

Proceedings of the AAAI Conference on Artificial Intelligence and Interactive Digital Entertainment, 2012
Organizers and program committee for the Intelligent Narrative Technologies 2012 AIIDE ...
openaire   +10 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Avaliação do crescimento de tecidos e órgãos de novilhos mestiços Holandês-Gir durante o ganho compensatório. 2. Tecidos e órgãos Evaluation of growth of tissues and organs of crossbreed Holstein-Gyr steers during compensatory growth. 2. Tissues and organs

Revista Brasileira de Zootecnia, 2001
O objetivo deste trabalho foi analisar os efeitos da restrição alimentar anterior ao confinamento sobre o crescimento e a composição química de tecidos e órgãos corporais em bovinos.
Maria Izabel Vieira de Almeida, Carlos Augusto de Alencar Fontes, Fernando Queiroz de Almeida, Augusto César de Queiroz, Rodrigo Furtado Guimarães   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Carcass characteristics and body components of Santa Inês lambs in feedlot fed on different levels of forage cactus meal

Revista Brasileira de Zootecnia, 2011
The objective of this study was to evaluate the effect of the replacement of a ground corn diet by a forage cactus meal diet on the carcass characteristics and body components of Santa Inês lambs finished in feedlot. This study was carried out at Estação
José Rômulo Soares dos Santos, Marcílio Fontes Cezar, Wandrick Hauss de Sousa, Maria das Graças Gomes Cunha, José Morais Pereira Filho, Dannylo Oliveira de Sousa   +5 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source