Results 241 to 250 of about 343,705 (317)
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Management of divergent stances as a resource to maintain progressivity and social relationships. [PDF]
Front PsycholLogren A, Ilomäki S, Ruusuvuori J.
europepmc +1 more source
Psychodinamically oriented nursing care of psychotic patients on a psychiatricward
, 2004 Kristjan Nedog
openalex +1 more source
Localized Wnt-signaling promotes asymmetric NuMA-dependent oriented divisions and unequal apportioning of mitochondria. [PDF]
Nat CommunEli S +21 more
europepmc +1 more source
Lateral approach in robotic aortic valve replacement: optimizing visualization from the orient and down under. [PDF]
Ann Cardiothorac SurgChen JW, Chi NH.
europepmc +1 more source