A Modular and Programmable Cas13d Platform for RNA Single Nucleotide Variant Detection
A scenario‐guided Cas13d platform enables configurable single nucleotide variant ribonucleic acid diagnostics through rule‐based guide design and ribonucleic acid binding domain engineering, supporting amplification‐free ultrasensitive detection and amplification‐coupled robust detection for accurate mutation classification in clinical tumor specimens.
Zeyu Wang +8 more
wiley +1 more source
BDH1 Mediates Aerobic Exercise-Induced Improvement in Skeletal Muscle Metabolic Remodeling in Type 2 Diabetes Mellitus. [PDF]
Wu M +6 more
europepmc +1 more source
Beneficial Effects of Different Types of Exercise on Diabetic Cardiomyopathy. [PDF]
Ma X +8 more
europepmc +1 more source
ABSTRACT Understanding how many species exist on Earth is a fundamental yet challenging question in biology, with significant implications for biodiversity conservation. The Linnean shortfall, or the gap in taxonomic knowledge, remains a major obstacle, particularly in highly diverse groups like insects. This study focuses on the family Leptophlebiidae
Myllena Lima +10 more
wiley +1 more source
<sup>68</sup>Ga/<sup>177</sup>Lu-labeled nectin4-targeted covalent bicyclic peptide: a novel nectin-4-targeted radioligands for theranostic of urothelial carcinoma. [PDF]
Sun L +12 more
europepmc +1 more source
Phase‐Transition‐Induced Fluorescence Changes in a Calamitic Liquid Crystal With an AIEgen Mesogen
Combining aggregation‐induced emission (AIE) with liquid crystals holds promise for multifunctional materials but is yet to be fully investigated. Here, we report an AIE‐active liquid crystal exhibiting smectic A (SmA) and nematic (N) phase, changes its fluorescence intensity discontinuously with SmA‐N phase transition in response to altered ...
Yuuto Iida +6 more
wiley +1 more source
Angiotensin II impairs the remyelination mediated by brain endothelial cell-derived exosomes. [PDF]
Yuan Y +7 more
europepmc +1 more source
The impacts of biological invasions
ABSTRACT The Anthropocene is characterised by a continuous human‐mediated reshuffling of the distributions of species globally. Both intentional and unintentional introductions have resulted in numerous species being translocated beyond their native ranges, often leading to their establishment and subsequent spread – a process referred to as biological
Phillip J. Haubrock +42 more
wiley +1 more source
MSFN-YOLOv11: A Novel Multi-Scale Feature Fusion Recognition Model Based on Improved YOLOv11 for Real-Time Monitoring of Birds in Wetland Ecosystems. [PDF]
Wang L, Ye L, Chen X, Chu N.
europepmc +1 more source
ABSTRACT Introduction Approximately 12.4% of patients with lung cancer experience depression after cancer diagnosis. Asian, Native Hawaiian, and Pacific Islanders (ANHPIs) constitute a large group with heterogeneity. The aim of this study is to examine the racial differences in depression risk, comparing overall ANHPI and ANHPI ethnic groups to non ...
Yancen Pan +7 more
wiley +1 more source

