Results 161 to 170 of about 41,081 (291)

Suppression of Indoleamine 2,3‐Dioxygenase Enhances Immune Responses to the Therapeutic Vaccine for Chronic Hepatitis B

open access: yesHepatology Research, EarlyView.
Indoleamine 2,3‐dioxygenase (IDO) activity modulates immune responses to the therapeutic HBV vaccine NASVAC. Genetic or pharmacological suppression of IDO enhanced vaccine efficacy in mice, and lower serum kynurenine levels predicted favorable responses in humans, suggesting IDO as both a therapeutic target and a biomarker.
Yohei Shirakami   +15 more
wiley   +1 more source

Genome assembly of Elcysma westwoodi provides insights into host‐plant cyanogenic glucoside detoxification and chemical defence gene evolution

open access: yesInsect Molecular Biology, EarlyView.
A chromosome‐level genome of Elcysma westwoodi was assembled. The genome encodes 272 detoxification‐related genes. A single‐copy bCAS was retained for cyanide detoxification. CYP405A and CYP332A were recruited into cyanogenic defence evolution. UGT33A retained a conserved GT‐B fold and catalytic domains.
Minyoung Choi, Murtaza Khan, Juil Kim
wiley   +1 more source

Influence of Different Multilayer Zirconia Materials on the In Vitro Load‐Bearing Capacity of Resin‐Bonded Fixed Partial Dentures in the Posterior Region

open access: yesJournal of Esthetic and Restorative Dentistry, EarlyView.
ABSTRACT Objective Comparison of the load‐bearing capacity and failure pattern of posterior resin‐bonded fixed partial dentures (RBFPDs) differing in retainer design, zirconia material, and vertical nesting position. Materials and Methods RBFPDs replacing a maxillary first molar were fabricated with 2 retainer designs (inlay‐retained, IR; wing‐retained,
Moritz Waldecker   +4 more
wiley   +1 more source

Solenostomus snuffleupagus sp. nov., a hairy ghost pipefish (Teleostei: Solenostomidae) from the Southwest Pacific, with an integrative comparison to S. paegnius

open access: yesJournal of Fish Biology, EarlyView.
Abstract A new species of ghost pipefish, Solenostomus snuffleupagus sp. nov., is described from the Coral Sea based on specimens (18–34 mm SL) collected from coral reef habitats in Queensland, Australia. The species is diagnosed by the following combination of characters: abundant elongate integumentary filaments imparting a conspicuously shaggy ...
Graham Short, David Harasti
wiley   +1 more source

Postnatal developmental changes in the laryngeal chemosensory cell clusters of rats

open access: yesJournal of Anatomy, EarlyView.
Chemosensory cell clusters appeared in the rat larynx 2 days after birth and were already connected to afferent nerve fibers. Their number increased until 3 weeks of age, then stabilized while continuing to grow through the addition of new cells. Because their number reached a plateau around the time of weaning, their development may be linked to ...
Sayed Sharif Abdali   +5 more
wiley   +1 more source

Settler Sociology: Eugenic Responses to Imperial Crises in the 20th Century

open access: yesSociology Lens, EarlyView.
ABSTRACT In the twentieth century, academic concerns about changes in the racial demographics of the United States emanated from the potential crisis of settler colonial decline. In their references to previous empires, stories of contact between people groups, and changes in demographics, settler scholars worked to provide solutions to the ever ...
Heidi Nicholls
wiley   +1 more source

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