Results 161 to 170 of about 232,101 (310)

Targeting the noradrenergic‐metabolic axis: A new strategy for sugar‐induced depression subtypes

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Lifestyle is closely related to major depressive disorder (MDD). Given the growing focus on the impact of diet on mental health, this study examined how dietary habits affect the pathophysiology of MDD. Experimental Approach Health check‐up data were analysed. Mice received sucrose under chronic unpredictable mild stress
Takatoshi Sakata   +13 more
wiley   +1 more source

In‐Tumor CRISPR‐Cas9 Knockout Screening and Novel Therapy Development for Malignant Transformation of Ovarian Teratoma

open access: yesCancer Science, EarlyView.
We conducted an in vivo genome‐wide CRISPR‐Cas9 knockout screen using MTMCT‐derived cells to identify genes essential for tumor growth. SOD1 emerged as a key therapeutic target, and its inhibition suppressed tumor proliferation by disrupting redox homeostasis, both in vitro and in PDX models. ABSTRACT Malignant transformation of mature cystic teratoma (
Satoshi Tamauchi   +8 more
wiley   +1 more source

Addressing environmental misperceptions for nature recovery

open access: yesConservation Biology, EarlyView.
Abstract A poorly understood and systemic challenge to global conservation agreements is shifting baseline syndrome (SBS), wherein people misperceive the extent to which nature has changed. This can diminish societal expectations for nature recovery. We broadened the conceptual framing of SBS beyond the more common elements of nature loss to include ...
Shuo Gao   +3 more
wiley   +1 more source

From plant to fabric: Environmental opportunities associated with annatto dye for sustainable development in the textile industry

open access: yesColoration Technology, EarlyView.
Abstract Natural dyes are compounds that occur naturally in several organisms and are classified based on chemical structure and application method. The literature cites several natural dyes used in industrial transformation processes. Annatto dye is used in the food industry, and its biological pigment is extracted from the annatto seed. However, this
Marcel Jefferson Gonçalves   +5 more
wiley   +1 more source

China inside out: Explaining silver flows in the triangular trade, c. 1820s‒70s

open access: yesThe Economic History Review, EarlyView.
Abstract This paper analyses a new large dataset of silver prices, as well as silver and merchandise trade flows in and out of China in the crucial decades of the mid‐nineteenth century when the Empire was opened to world trade. Silver flows were associated with the interaction between heterogeneous monetary preferences and availability of specific ...
Alejandra Irigoin   +2 more
wiley   +1 more source

Prevalence of Congenital Malformations in the Oriental Region of Morocco. [PDF]

open access: yesCureus
Erraoui I   +4 more
europepmc   +1 more source

The caliph and the falcons: a ninth‐century history from Iceland to Iraq

open access: yesEarly Medieval Europe, EarlyView.
In the late ninth and early tenth centuries, an extraordinary number of falcons were given to the ʿAbbāsid caliphs in Baghdad, many of which were white. Gifts from competing dynasties in the northern provinces of the Caliphate, at least some of these birds were almost certainly gyrfalcons from near the Arctic Circle.
Caitlin Ellis, Sam Ottewill‐Soulsby
wiley   +1 more source

Sacubitril/Valsartan Attenuates Inflammation and Fibrosis Associated With Decreased Integrin α8 and Inhibits Hepatocarcinogenesis in a Rat Model of Metabolic Dysfunction‐Associated Steatohepatitis

open access: yesHepatology Research, EarlyView.
Sacubitril/Valsartan (Sac/Val) alleviates fibrosis and inflammation in metabolic dysfunction‐associated steatohepatitis (MASH). Its anti‐fibrotic effect is linked to the suppression of Integrin alpha 8 (Itga8), a protein crucial for hepatic stellate cell (HSC) activation and collagen production.
Hayato Kawamura   +11 more
wiley   +1 more source

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