Results 201 to 210 of about 191,593 (349)

Sacubitril/Valsartan Attenuates Inflammation and Fibrosis Associated With Decreased Integrin α8 and Inhibits Hepatocarcinogenesis in a Rat Model of Metabolic Dysfunction‐Associated Steatohepatitis

open access: yesHepatology Research, EarlyView.
Sacubitril/Valsartan (Sac/Val) alleviates fibrosis and inflammation in metabolic dysfunction‐associated steatohepatitis (MASH). Its anti‐fibrotic effect is linked to the suppression of Integrin alpha 8 (Itga8), a protein crucial for hepatic stellate cell (HSC) activation and collagen production.
Hayato Kawamura   +11 more
wiley   +1 more source

Suppression of Indoleamine 2,3‐Dioxygenase Enhances Immune Responses to the Therapeutic Vaccine for Chronic Hepatitis B

open access: yesHepatology Research, EarlyView.
Indoleamine 2,3‐dioxygenase (IDO) activity modulates immune responses to the therapeutic HBV vaccine NASVAC. Genetic or pharmacological suppression of IDO enhanced vaccine efficacy in mice, and lower serum kynurenine levels predicted favorable responses in humans, suggesting IDO as both a therapeutic target and a biomarker.
Yohei Shirakami   +15 more
wiley   +1 more source

Genome and transcriptome‐based identification and expression profiling of chemosensory gene families across developmental stages and tissues in Sirex noctilio (Hymenoptera: Siricidae)

open access: yesInsect Molecular Biology, EarlyView.
The first draft genome of Sirex noctilio was produced. Fifteen S. noctilio transcriptomes were sequenced to study chemosensory gene expression patterns. SnocOR16 and SnocSNMP1 displayed tissue‐ and sex‐specific expression patterns. Abstract The Sirex woodwasp (Sirex noctilio; Hymenoptera: Siricidae) is among the most destructive invasive pests ...
Alisa Postma   +21 more
wiley   +1 more source

Surrogate Decision‐Making Practices Regarding End‐of‐Life Care for People With Dementia in Long‐Term Care Hospitals: A Qualitative Descriptive Study

open access: yesJournal of Advanced Nursing, EarlyView.
ABSTRACT Aim To explore surrogate decision‐making practices regarding end‐of‐life care for people with dementia in Korean long‐term care hospitals from the perspective of healthcare providers. Design A qualitative descriptive study. Methods The data were collected through individual semi‐structured interviews with 24 healthcare providers (physicians ...
Hyejin Kim   +3 more
wiley   +1 more source

Investors’ Natural Disaster Experience and Cost of Raising Equity Capital: Evidence From Seasoned Equity Offering Pricing

open access: yesJournal of Business Finance &Accounting, EarlyView.
ABSTRACT We investigate whether and how investors’ experiences of natural disasters affect the cost of raising new equity in a setting of seasoned equity offerings (SEOs). Our proprietary database contains comprehensive information on geographical distribution, investor profiles, investor office location, and bidding specifics related to SEOs.
Shenghao Gao   +3 more
wiley   +1 more source

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