Results 101 to 110 of about 5,350,711 (346)

The Origin of Life in the Universe [PDF]

open access: yesProc.of AP Akademi of Sciences Vol.6,No.2, 2002(Special Issue on Astrnomy), 2002
Terrestrial and extraterrestrial theories of the origin of life are discussed in the light of latest observations. The available data suggest a dual mode of origin, some of the ingredients, including possibly sugars, were brought to earth from outer space, which combined with other ingredients, such as proteins, already available on the earth leading ...
arxiv  

A histidine‐rich extension of the mitochondrial F0 subunit ATP6 from the ice worm Mesenchytraeus solifugus increases ATP synthase activity in bacteria

open access: yesFEBS Letters, EarlyView.
The glacier ice worm Mesenchytraeus solifugus survives year‐round at 0 °C. Its ATP6 subunit, which forms a regulatory component of the proton pore in mitochondrial ATP synthase, has a carboxy‐terminal extension not found in any other organism examined to date. Here, we show that fusion of this extension to the homologous AtpB protein in E. coli results
Truman Dunkley   +2 more
wiley   +1 more source

RNA origin of life [PDF]

open access: yes, 2010
RNA molekula sadrži genetičku informaciju i ima katalitičku ulogu, te je stoga možemo smatrati pramolekulom života. Njena uloga je vrlo bitna i u danas u biologiji.
Bratovič, Majda
core   +2 more sources

Elucidation of interface interactions between a dehydratase domain and an acyl carrier protein in cremimycin polyketide synthase

open access: yesFEBS Letters, EarlyView.
In modular polyketide synthases, the dehydratase (DH) domain catalyzes the dehydration reaction of the β‐hydroxyacyl unit attached to the cognate acyl carrier protein (ACP) domain. However, it is unclear how DH interacts with ACP during the reaction. In this study, we identified DH–ACP interface residues, providing the first detailed insights into DH ...
Kaede Kotagiri   +8 more
wiley   +1 more source

Origin of life [PDF]

open access: yes
The pathways of organic chemical synthesis, the chemical evolution on the early Earth leading to life was constrained by the development of the planet by accretion and core formation.
Chang, S.
core   +1 more source

Motility at the origin of life: Its characterization and a model

open access: yes, 2013
Due to recent advances in synthetic biology and artificial life, the origin of life is currently a hot topic of research. We review the literature and argue that the two traditionally competing "replicator-first" and "metabolism-first" approaches are ...
Froese, Tom   +2 more
core   +1 more source

A Fundamentally New Perspective on the Origin and Evolution of Life [PDF]

open access: yesPioneer 3: 7-17, 2008 (http://im1.biz), 2008
Darwin's hypothesis that all extant life forms are descendants of a last common ancestor cell and diversification of life forms results from gradual mutation plus natural selection represents a mainstream view that has influenced biology and even society for over a century.
arxiv  

Functional variation among LPMOs revealed by the inhibitory effects of cyanide and buffer ions

open access: yesFEBS Letters, EarlyView.
This study addresses the inhibition of lytic polysaccharide monooxygenases (LPMOs) by cyanide and explains how and why the magnitude of observed inhibitory effects depends on the way LPMO reactions are setup and on the type of LPMO. Enzymes known as lytic polysaccharide monooxygenases (LPMOs) are mono‐copper polysaccharide‐degrading peroxygenases that ...
Ole Golten   +10 more
wiley   +1 more source

Life Before Earth [PDF]

open access: yesarXiv, 2013
An extrapolation of the genetic complexity of organisms to earlier times suggests that life began before the Earth was formed. Life may have started from systems with single heritable elements that are functionally equivalent to a nucleotide. The genetic complexity, roughly measured by the number of non-redundant functional nucleotides, is expected to ...
arxiv  

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

open access: yesFEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung   +6 more
wiley   +1 more source

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