Results 101 to 110 of about 2,987,022 (341)
FEBS Letters, EarlyView.Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello +6 more
wiley +1 more source
Investigation of compounds essential for the origin of life [PDF]
Nucleic acid sequencing as a technique to determine the chemical and biological evolution of certain prokaryotic metabolic pathways is discussed.
Dayhoff, M. O., Hunt, L. T.
core +1 more source
Characteristics of synbiotics and lactobionic acid
Journal of Functional FoodsThis analysis delves into the combined advantages of synbiotics - a mix of probiotics and prebiotics, in supporting gut health and overall wellness. Synbiotics have displayed potential in enhancing function reducing inflammation and promoting digestion ...
Kamila Goderska, Peace Oluwamuyiwa Obey
doaj +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Hematopoietic (stem) cells—The elixir of life?
FEBS Letters, EarlyView.The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source
Exobiology and the origin of life [PDF]
Research supported wholly or in part by NASA is summarized, Topics covered include the molecular analysis of ultraviolet-photoproduced organic solids synthesized under simulated Jovian conditions; the molecular analysis of organic solids produced by ...
Sagan, C.
core +4 more sources
Non-equilibrium Thermodynamic Foundations of the Origin of Life
, 2022 Karo Michaelian
openalex +2 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source