Results 141 to 150 of about 2,987,022 (341)
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
On the origin of life: an RNA-focused synthesis and narrative. [PDF]
RNA, 2023 Fine JL, Pearlman RE.
europepmc +1 more source
The Long-Term Life-Cycle of Nevado de Toluca Volcano (Mexico): Insights Into the Origin of Petrologic Modes [PDF]
, 2020 Gregor Weber +2 more
openalex +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Scientific returns from a program of space missions to comets [PDF]
A program of cometary missions is proposed. The nature and size of interstellar dust, its origin and evolution; identification of new interstellar molecules; clarification of interstellar chemistry; accretion of grains into protosolar cometesimals; role ...
Delsemme, A. H.
core +1 more source
Role of Stress in the Origin of Life. [PDF]
Life (Basel), 2022 Kompanichenko V, Kotsyurbenko O.
europepmc +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source