Results 141 to 150 of about 5,350,711 (346)

The solution supramolecular structure of α2 → 8 polysialic acid suggests a structural cause for its low immunogenicity

open access: yesFEBS Letters, EarlyView.
α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley   +1 more source

Proto-Neurons from Abiotic Polypeptides

open access: yesEncyclopedia
To understand the origins of life, we must first gain a grasp of the unresolved emergence of the first informational polymers and cell-like assemblies that developed into living systems. Heating amino acid mixtures to their boiling point produces thermal
Panagiotis Mougkogiannis   +1 more
doaj   +1 more source

Origin of Quantum Mechanical Results and Life: A Clue from Quantum Biology [PDF]

open access: yes, 2018
Although quantum mechanics can accurately predict the probability distribution of outcomes in an ensemble of identical systems, it cannot predict the result of an individual system.
Dikshit, Biswaranjan
core  

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

The Moon-Forming Impact and the Autotrophic Origin of Life. [PDF]

open access: yesChempluschem, 2023
Mrnjavac N   +4 more
europepmc   +1 more source

Three-stage Origin of Life as a Result of Directional Darwinian Evolution [PDF]

open access: yesarXiv, 2012
The original hypothesis about Three-stage origin of life (TOL) on the Earth is developed and discussed. The role of the temperature factor in life origin is considered. It is supposed, that three stages of abiogenesis (DNA world, RNA world and the Protein world) consistently followed each other during Darwinian evolution.
arxiv  

Flow‐based immunomagnetic enrichment of circulating tumor cells from diagnostic leukapheresis product

open access: yesMolecular Oncology, EarlyView.
The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens   +8 more
wiley   +1 more source

A semi-quantum version of the game of Life [PDF]

open access: yesin Advances in Dynamic Games: Applications to Economics, Finance, Optimization, and Stochastic Control, eds A. S. Nowack and K. Szajowski (Boston: Birkhauser, 2004) pp. 649-61, 2002
A version of John Conway's game of Life is presented where the normal binary values of the cells are replaced by oscillators which can represent a superposition of states. The original game of Life is reproduced in the classical limit, but in general additional properties not seen in the original game are present that display some of the effects of a ...
arxiv  

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

open access: yesMolecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever   +1 more
wiley   +1 more source

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