Results 231 to 240 of about 5,350,711 (346)
Primordial organic chemistry and the origin of life [PDF]
, 1971 Cyril Ponnamperuma
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Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer
Molecular Oncology, EarlyView.This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu +7 more
wiley +1 more source
Autocatalytic Selection as a Driver for the Origin of Life. [PDF]
Life (Basel)Williamson MP.
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From the origin of life to pandemics: emergent phenomena in complex systems. [PDF]
Philos Trans A Math Phys Eng Sci, 2022 Artime O, De Domenico M.
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KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells
Molecular Oncology, EarlyView.We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock +10 more
wiley +1 more source
Pinpointing Conditions for a Metabolic Origin of Life: Underlying Mechanisms and the Role of Coenzymes. [PDF]
Acc Chem ResZimmermann J +3 more
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Molecular Oncology, EarlyView.Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy +12 more
wiley +1 more source
Pioneers of Origin of Life Studies-Darwin, Oparin, Haldane, Miller, Oró-And the Oldest Known Records of Life. [PDF]
Life (Basel)Schopf JW.
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