Results 241 to 250 of about 2,987,022 (341)

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Materials of the Third Conference of Young Scientists, dedicated to Charles Darwin's 200th Birthday and the 150th Anniversary of the publication of his main book «On the Origin of Species by Means of Natural Selection, or the Preservation of Favoured Races in the Struggle for Life» (9-10 June 2009) [PDF]

, 2009
Olena V. Balynska, A Iershov, V. V. Dmitrenko, V. M. Kavsan, Konstantin S. Boyarshin, I. A. Kriklivyi, A. Yaremchuk, Ì Tukalo, Oleksandr Dergai, Mykola Dergai, I Ya, L Skrypkina, G Tsyba, A. V. Rynditch, O Martsenyuk, Bettina Huppertz, Min Yu, M Yu, Obolenskaya   +18 more
openalex   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Pioneers of Origin of Life Studies-Darwin, Oparin, Haldane, Miller, Oró-And the Oldest Known Records of Life. [PDF]

Life (Basel)
Schopf JW.
europepmc   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Three Biopolymers and Origin of Life Scenarios. [PDF]

Life (Basel)
Agmon I.
europepmc   +1 more source

Learning to Code: tRNA and the Origin of Life

Zachary F. Burton
openalex   +1 more source

Origins of Life [PDF]

Oceanography, 2003
openaire   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Interstellar Ices: A Factory of the Origin-of-Life Molecules. [PDF]

ACS Cent Sci
Puzzarini C, Alessandrini S.
europepmc   +1 more source