Results 251 to 260 of about 838,055 (333)
Sporulation, bacterial cell envelopes and the origin of life
E. Tocheva, Davi R. Ortega, G. Jensen
semanticscholar +1 more source
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho+11 more
wiley +1 more source
Opinion: The Key Steps in the Origin of Life to the Formation of the Eukaryotic Cell. [PDF]
Brunk CF, Marshall CR.
europepmc +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski+19 more
wiley +1 more source
Correction to 'Origin of life: protoribosome forms peptide bonds and links RNA and protein dominated worlds'. [PDF]
europepmc +1 more source
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau+9 more
wiley +1 more source
Chemobrionics and the Origin of Life
ALIFE: The 2019 Conference on Artificial Life, in Newcastle (U.K.), 29tj july 2nd agust ...
openaire +2 more sources