Results 261 to 270 of about 5,350,711 (346)

The Origins of Life: From the Birth of Life to the Origin of Language [PDF]

, 1999
Wallace Arthur
openalex   +1 more source

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

Opinion: The Key Steps in the Origin of Life to the Formation of the Eukaryotic Cell. [PDF]

Life (Basel)
Brunk CF, Marshall CR.
europepmc   +1 more source

The Coevolution of Biomolecules and Prebiotic Information Systems in the Origin of Life: A Visualization Model for Assembling the First Gene. [PDF]

Life (Basel), 2022
Chatterjee S, Yadav S.
europepmc   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

The Romance of Real Life: Charles Brockden Brown and the Origins of American Culture. [PDF]

, 1995
Mary Kupiec Cayton, Steven Watts
openalex   +1 more source

The Geological Aspects of the Origin of Life on Earth

, 1963
M. G. Rütten
openalex   +2 more sources

Europa's Crust and Ocean: Origin, Composition, and the Prospects for Life [PDF]

, 2000
Jeffrey S. Kargel, Jonathan Z. Kaye, J. W. Head, G. M. Marion, Roger Sassen, James K. Crowley, O. Prieto‐Ballesteros, Steven A. Grant, D. L. Hogenboom   +8 more
openalex   +1 more source

Origin of life [PDF]

Nature, 1989
Jeffrey L. Bada, Stanley L. Miller
openaire   +2 more sources

Peripheral blood leukocyte signatures as biomarkers in relapsed ovarian cancer patients receiving combined anti‐CD73/anti‐PD‐L1 immunotherapy in arm A of the NSGO‐OV‐UMB1/ENGOT‐OV30 trial

Molecular Oncology, EarlyView.
Using mass cytometry, we analyzed serial blood samples from patients with relapsed epithelial ovarian cancer (EOC) treated with oleclumab–durvalumab combination immunotherapy in the NSGO‐OV‐UMB1/ENGOT‐OV30 trial. Our analysis identified potential predictive, monitoring, and response biomarkers detectable through liquid biopsy. These findings facilitate
Luka Tandaric, Annika Auranen, Katrin Kleinmanns, René DePont Christensen, Liv Cecilie Vestrheim Thomsen, Cara Ellen Wogsland, Emmet McCormack, Johanna Mäenpää, Kristine Madsen, Karen Stampe Petersson, Mansoor Raza Mirza, Line Bjørge   +11 more
wiley   +1 more source