Results 301 to 310 of about 3,122,038 (384)

Natural soda lakes provide compatible conditions for RNA and membrane function that could have enabled the origin of life. [PDF]

PNAS Nexus
Cohen ZR, Ding D, Zhou L, DasGupta S, Haas S, Sinclair KP, Todd ZR, Black RA, Szostak JW, Catling DC.   +9 more
europepmc   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Natural Philosophy of Protoplanetary and Planetary Discs: On the Origin and Evolution of Life

Xiaoming Li
openalex   +1 more source

The System View of the Origin of Cellular Life

, 2018
Pier Luigi Luisi, Luisi Pl, P Bachmann, P Luisi, J Lang, P Walde, R Wick, M Fresta, P Walde, A Goto, P Monnard, T Oberholzer, K Nierhaus, P Luisi, T Oberholzer, P Luisi, P Luisi, F Ferri, P Stano, A Chakrabarti, R Breaker, G Joye, T Oberholzer, R Wick, P Luisi, P Schmidli, P Schurtenberger, P Luisi, Y Shimizu, A Inoue, Y Tomari, Y Shimizu, T Kanamori, T Ueda, G Murtas, Y Kuruma, P Bianchini, T Sunami, K Sato, T Matsuura, S Nomura, K Tsumoto, T Hamada, K Nishimura, T Matsuura, K Nishimura, T Nishikawa, T Sunami, T Matsuura, T Souza, P Stano, P Luisi, A Mushegian, A Mushegian, A Mushegian, E Koonin, L Shimkets, R Gil, B Sabater-Munoz, A Latorre, S Islas, A Becerra, P Luisi, R Gil, F Silva, J Pereto, C Hutchinson, S Peterson, S Gill, C Hutchinson, R Chuang, V Noskov, P Luisi, M Allegretti, T De Souza, T Souza, P Stano, F Steiniger, P Stano, D 'aguanno, E Bolz, J, T Souza, Volpe Bossa, G Stano, P, F Mavelli, E Altamaura, L Cassidei, P Uster, D Deamer, D Pantazatos, R Mcdonald, T Sunami, F Caschera, Y Morita, F Caschera, T Sunami, T Matsuura, J Errington   +99 more
openalex   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Family-of-origin aggression, dating aggression, and physiological stress reactivity in daily life

, 2019
Adela C. Timmons, Sohyun C. Han, Theodora Chaspari, Yehsong Kim, Corey Pettit, Shrikanth Narayanan, Gayla Margolin   +6 more
openalex   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

The SOL $\textit{(Solar Origin and Life)}$ Project: Detailed characterization of candidates for the ZAMS and Subgiant stages [PDF]

C. Eduardo-Oliveira S., L. Ghezzi, G. F. Porto de Mello, D. Lorenzo-Oliveira, P. V. Souza dos Santos, E. Costa-Almeida   +5 more
openalex  

Nuclear geyser model of the origin of life: Driving force to promote the synthesis of building blocks of life

, 2016
Toshikazu Ebisuzaki, Shigenori Maruyama
openalex   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source