Results 121 to 130 of about 7,148,565 (315)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Procedimientos automáticos de creación y transformación de los registros bibliográfico

open access: yesAnales de Documentación, 2001
El objeto de este artículo es exponer qué se puede hacer, qué se debe hacer, qué hay que hacer para transformar los catálogos manuales en catálogos legibles por ordenador y cuales son algunos de los regímenes que imperan en este tipo de ...
María Rosa Garrido Arilla
doaj  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Original art print, "Spirit of Flight" [PDF]

open access: yes, 1989
Framed and matted original art print "Spirit of Flight," by Pat Whipp, commissioned in 1989 by the National Aviation Hall of Fame in Dayton, Ohio.Physical Dimensions: 10 inches high by 12 inches wide.Credit: John Glenn Archives, The Ohio State ...
Whipp, Pat
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Unveiling the Huge Yearning for Generating: An Authentically American Literary Production

open access: yesTraduction et Langues, 2016
No wonder, every country strives for uniqueness and authenticity in what comes to its literary production. This paper involves exploring the way some American writers imitated and reproduced the European literary tradition for a long time and how they ...
Sara Boutouil
doaj  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Manchester : the original modern city [PDF]

open access: yes, 2007
A critical account of Manchester's 'organising concept' - original ...
O'Connor, Justin
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Creatividad y comunicación en César Vallejo, autor y traductor

open access: yesMutatis Mutandis, 2010
Nuestra intención es mostrar de qué manera puede evidenciarse una influencia mutua entre los estilos del autor del original y los de su traductor, tomando como ejemplos a Marcel Aymé y a César Vallejo, como traductor de La rue sans nom.
Rosario Valdivia Paz-Soldán
doaj  

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