Results 111 to 120 of about 5,511,969 (335)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Gordon Craig’s Scene Project: a history open to revision

Revista Brasileira de Estudos da Presença, 2014
The article proposes a review of Gordon Craig’s Scene project, an invention patented in 1910 and developed until 1922. Craig himself kept an ambiguous position whether it was an unfulfilled project or not.
Luiz Fernando Ramos (University of São Paulo, São Paulo/SP, Brazil)
doaj   +2 more sources

A Study on Water Modeling Simulation for Slag Entrapment in 100 t Ladle with Bottom Argon Blowing during LF Refining Process

Teshugang, 2014
According to the prototype of a 100 t ladle at steelworks and based on geometric similarity principle, a water model with model and prototype ratio 1:3.5 is established.
田罗林, 岳峰, 吴华杰, 李瑛, 马忠存, 李彬   +5 more
doaj  

Study of the Similarities in Scale Models of a Single-Layer Spherical Lattice Shell Structure under the Effect of Internal Explosion

Shock and Vibration, 2017
The similarity of each scale model is verified based on the theory of similarity, deriving the similarity law of internal explosions in a single-layer spherical lattice shell structure via dimensional theory, calculated based on models with scaling ...
Wenbao Wang, Xuanneng Gao, Lihui Le
doaj   +1 more source

Study on the consistency of the position of the brackets on the digital occlusal model and the actual position af⁃ ter indirect bonding

口腔疾病防治, 2017
Objective To provide the experimental basis for the coherence of the indirect bond position by compar⁃ ing the position of the bracket on the digital occlusal model and the position of the transfer to the initial plaster model.
BAO Li ⁃ na
doaj   +1 more source

Emergency surgeon: “ last of the mohicans” 2014-2016 editorial policy WSES- WJES: position papers, guidelines, courses, books and original research; from WJES impact factor to WSES congress impact factor [PDF]

, 2014
Fausto Catena, Frederick A. Moore, Luca Ansaloni, Ari Leppäniemi, Massimo Sartelli, Andrew Peitzmann, Walt Biffl, Federico Coccolini, Salomone Di Saverio, Belinda De Simone, Michele Pisano, Ernest E. Moore   +11 more
openalex   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Religious Majoritarianism and Democratic Experiences of South asia and the Original Position of minority class

, 2021
Soumen Bhattacharya
openalex   +1 more source

Animals in the Original Position

Between the Species: An Online Journal for the Study of Philosophy and Animals, 1992
In A Theory of Justice, John Rawls l defends two principles of justice by means of an appeal to a hypothetical "original position." However, these principles are strictly principles of justice by and for human beings, or at least by and for persons. Several philosophers have recently argued that tllis argument is flawed-is "speciesist"-in tllat there ...
openaire   +3 more sources

Is the Veil of Ignorance Transparent ? [PDF]

Theories of justice in the spirit of Rawls and Harsanyi argue that fair-minded people should aspire to make choices for society as if in the original position, that is, behind a veil of ignorance that prevents them from knowing their own social positions
Cécile Renouard, Gaël Giraud
core