Results 171 to 180 of about 5,486,911 (302)

PyTEA-O: a Python implementation of Two-Entropies Analysis for protein sequence variation analysis. [PDF]

Bioinformatics
Kuin RCM, Julian AT, Chander J, Lee S, van Westen GJP.   +4 more
europepmc   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Heads Down for Acute Stroke: Supine Position for Acute Large Vessel Occlusion in Ischemic Stroke. [PDF]

Clin Case Rep
Khan HA, Thomas EJ, Zackariya SK, Kelly KM, Zackariya SK, Qasim Z, Buchh M, Khan AS, Ansari HK, Lankford HP, Van Ryn LK, Howell CC, Al-Fadhl MD, Karam MN, Thomas AV, Gonzalez R, Shariff FS, Alizai AM, Zimmer DF, Marsee MK, Walsh MM.   +20 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

FDNHSA's response to KL Dunkle et al.'s 'Upholding clinical integrity and South African relevance: A defence of the SASOP position statement on the care of transgender and non-binary youth'. [PDF]

S Afr J Psychiatr
Donkin A, Rodseth R, Giddy J.
europepmc   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Flexible intubating video endoscope-guided determination of optimal oral endotracheal tube depth in infants: a prospective observational study. [PDF]

Front Med (Lausanne)
Yue K, Peng X, Wang J, Xu Y, Sun Y, Xia Y.   +5 more
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Correction: A complete benchmark for polyp detection, segmentation and classification in colonoscopy images. [PDF]

Front Oncol
Tudela Y, Majó M, de la Fuente N, Galdran A, Krenzer A, Puppe F, Yamlahi A, Tran TN, Matuszewski BJ, Fitzgerald K, Bian C, Pan J, Liu S, Fernández-Esparrach G, Histace A, Bernal J.   +15 more
europepmc   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source