Results 61 to 70 of about 58,042,140 (212)
Medical Research Charities Group: Annual report 2018 [PDF]
, 2019 2018 was a year of high activity and much progress for the MRCG. Fourteen exciting research projects were funded through our Joint Funding Scheme with the HRB, two impactful Irish Health Research Forum events were held and we did much to support our ...
Medical Research Charities Group
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A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Biobanking in Ireland: Moving Forward. Irish Health Research Forum Recommendations and Event Report [PDF]
This report presents the proceedings of the Irish Health Research Forum on November 16th 2023, focusing on progressing biobanking in Ireland, and makes key recommendations for moving biobanking forward.Roche Products ...
Health Research Charities Ireland
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Electronic Cigarette Marketing: Current Research and Policy [PDF]
, 2016 This report outlines results from three separate but connected pieces of research. First, a review of the current e-cigarette market drawing on available data from market analysis, the trade press and other published sources. Secondly, a systematic rapid
Ford, Allison +3 more
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The determinants of "domestic" original sin in emerging market economies [PDF]
This paper explains why domestic debt composition in some emerging economies is risky. To this end, it carries out a systematic analysis of the determinants of the so-called domestic original sin, which refers to the inability of emerging economies to ...
Julien Reynaud, Arnaud Mehl
core +2 more sources
Summary of Research 1996, Department of Operations Research [PDF]
, 1996 The views expressed in this report are those of the authors and do not reflect the official policy or position of the Department of Defense or the U.S.
Faculty of the Department of Operations Research, Naval Postgraduate School
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Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Health research in action 2018 [PDF]
, 2018 Actions and outcomes enabled by HRB-funded ...
Health Research Board
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Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source